Colivelin Research

Hagan J, Griffin TP, Chauhan R, Choudhary P, Crabtree TSJ, Ackroyd D et al.

The NHS England hybrid closed-loop (HCL) insulin pump pilot offered people living with Type 1 diabetes (PWT1Ds) access to HCL therapy. Outcomes demonstrated the glycaemic benefits of HCL. Our study explored the views, experiences and impact of HCL on users and their partners' daily life.A total o...

Islam T, Yañez-Guerra LA, Semmens DC, Beskeen RT, Egertová M, Elphick MR et al.

The neurohormone kisspeptin regulates reproductive maturation and function in mammals by stimulating hypothalamic production and release of gonadotropin-releasing hormone. However, little is known about kisspeptin-type neuropeptide function in invertebrates and the evolution of kisspeptin signall...

Heinlein C, Mandal S, Jacob T, Paulus S, Sauermann L, Schuster M et al.

Nucleic acid therapeutics (NATs), including antisense oligonucleotides and small interfering RNAs, represent an expanding class of therapeutic modalities with distinctive physicochemical, pharmacokinetic, pharmacodynamic, and biodistribution properties. Naturally, their bioanalysis requires platf...

Zhou Y, Yang Z, Chen Y, Zhang R, Yang C, Lin Z et al.

A mild and green immobilization strategy was proposed based on catechol compounds and elastin-like peptides-SpyCatcher (EC), where ECs could specifically bind to the target enzyme chimera (xylanase-SpyTag-lichenase, XL) and offer suitable arm length between the chimera and carriers. The EC-functi...

He H, Fu Q, Yu X, Chen X, Lu J, Jin L et al.

POEMS syndrome is a rare hematologic condition with no established standard of therapy. Bortezomib, a proteasome inhibitor, has shown potential to offer significant clinical benefits for patients with newly diagnosed POEMS syndrome. However, comprehensive data on its long-term efficacy remain sca...

Mathew AE, Arivarasan VK

Nanobiomaterials-engineered constructs operating at the 1-100 nm scale-integrate biological macromolecules such as nucleic acids and proteins with synthetic polymers or inorganic nanocomponents to achieve programmable functionality in biomedical and industrial contexts. Representative system...

Denisova E, Avdyusheva A, Vasilieva V, Tyshchuk E, Grebenkina P, Korenevsky A et al.

The secretome of ESKAPE pathogens contains numerous bioactive molecules that play a key role in pathogenesis and the formation of an immunosuppressive microenvironment. However, analyzing this complex chemical composition presents significant methodological challenges. In this study, we propose a...

Anguita R, Li J, Boix E, Prats-Ejarque G

Biofilms are microbial communities embedded in an extracellular matrix that facilitates their attachment to surfaces. This lifestyle provides advantages to pathogenic bacteria, including increased survival in the presence of antibiotics and an enhanced capacity to develop resistance. Once a biofi...

Fang YJ, Yang XY, Xie LB, Zhang ZW, Yuan S

Eutrema salsugineum is a model species for studying stress resistance, particularly extreme salinity, and is often compared with Arabidopsis thaliana. Previous research has shown that basal salicylic acid (SA) levels are significantly lower in E. salsugineum than in A. thaliana. In this study, su...

Inokuma T, Miyamoto M, Okada K, Nagai G, Yamada KI

An enantioselective Mannich reaction of 2-(2-nitrophenylsulfenylimino)acetamide is described. Under the optimized conditions using proline, triethylamine, and diarylthiourea additives, the initially formed Mannich adduct undergoes irreversible cyclization to afford cyclic hemiaminal products in 2...

Bayoudh A, Tarhouni N, Sadraoui R, Hadrich B, Ursu AV, Pierre G et al.

Pseudomonas aeruginosa elastase LasB accelerates refrigerated food spoilage through proteolytic degradation of muscle and milk proteins. While Marrubium vulgare essential oil terpenes exhibit antimicrobial activity, their weak potency and nonspecificity limit direct food preservation applications...

Asl ZR, Rezaee K, Ansari M, Zare-Zardini H, Eslami H

Therapeutic anti-diabetic peptides (ADPs) are an emerging class of clinically-relevant biologics with the potential to manage glucose (glycaemic) levels. However, the majority of existing computational pipelines are either narrowly focused or unverified. Here, we present a principled, end-to-end,...

Wang B, Zhou S, Zhang X, Wang R, Huang S, Li A et al.

Accurate single-nucleotide discrimination of miRNA is clinically vital because small sequence variations can have significant phenotypic and clinical consequences, yet existing techniques can only detect single nucleotide variations (SNVs) at specific loci. Here, we present a generalized peptide ...

Zhao Y, Yang G, Zhang Z, Xie M, Liu J, Cheng Y et al.

Coronaviruses have repeatedly emerged in recent years, causing significant and ongoing threats to global public health. The development of therapeutic agents and strategies capable of responding to future outbreaks caused by emerging coronavirus variants remain an ongoing priority. Here, we engin...

Tang Z, Liu H, Zhao X, Li P, Du Y, Li S et al.

The clinical translation of nanomedicine for non-alcoholic fatty liver disease (NAFLD) is frequently hindered by rapid hepatic clearance mediated by Kupffer cells, which are the predominant phagocytic macrophages in the liver. Conventional stealth strategies, such as PEGylation, protect host cell...

Alias-Ferri M, Kersey CB, Shalen EF, Cook R, Gregoire D, Hoffman K et al.

Methamphetamine-associated heart failure (MAHF) is increasingly prevalent in rural communities, where limited specialty care and barriers to healthcare engagement hinder early diagnosis and treatment. Peer-led screening with brain natriuretic peptide (BNP) testing, supported by telemedicine, may ...

Kato M, Nakaji-Hirabayashi T, Matsumura K, Yoshikawa C, Usui Y, Kishioka T et al.

Cell transplantation therapy is a promising strategy for next-generation regenerative medicine. However, its clinical application is limited by the absence of safe and label-free methods for obtaining pure populations of functional cells. This study reports a peptide-functionalized zwitterionic p...

Li J, Wei L, Gao F, Zeng L, Jiang H, Chen L et al.

Aging imposes significant influence in alteration of organ structure, function, and susceptibility to disease. Long non-coding RNAs (lncRNAs) are frequently dysregulated in the aging kidney, however, the key lncRNAs and associated mechanism involved in regulating kidney aging remains poorly inves...

Akbar S, Raza A, Ullah M, Alghamdi W, Khan M, Zou Q et al.

Globally, cancer is a major health issue that poses a significant threat to human health. Traditional treatments and laboratory-based methods have been extensively employed to treat cancer-affected cells. However, their high processing costs and side effects still limit their efficacy. In the pas...

Uttarkar A, Niranjan V, Saxena A, Kumar V

Protein folding, and especially the conformational sampling of intrinsically disordered regions (IDRs), remains a formidable challenge for classical computation. We introduce QuPepFold, a modular Python package designed to democratize hybrid quantum-classical simulations of peptide folding, with ...