Colistin Research

Yadav NS, Raza S, Wang Y, Landa JF, Hegg EL, Hausinger RP et al.

Bacterial microcompartments (BMCs) are protein-based organelles found in diverse bacteria that encapsulate a sequence of enzymes to accelerate specific metabolic pathways and limit toxicity by confining intermediate products. To facilitate catalysis in BMCs, reactants and products must transit ac...

Vo TTB, Ha VTT, Nghiem MN

This study purposed to investigate the antibiotic susceptibility data and the expression of resistance genes in Acinetobacter baumannii clinical isolates obtained from a military hospital in Vietnam. Antimicrobial susceptibility testing was conducted using both the disc diffusion method and the V...

Korkmaz N, Şentürk GÇ, Yılmaz FA, Kul G, Güldoğan B, Yılmaz HM et al.

Klebsiella spp. causing bloodstream infections (BSIs) with resistance to carbapenems and/or colistin are associated with high mortality and limited treatment options. While procalcitonin (PCT) kinetics have prognostic value in other settings, their role in resistant Klebsiella spp. infections rem...

Smith BL, May A, Lalani F, Hasham S, Presnell AA

Obesity is a chronic, multifactorial disease associated with significant metabolic, physical, and psychosocial complications. Although advances in pharmacologic therapy-particularly glucagon-like peptide-1 (GLP-1)-based agents-have expanded treatment options, challenges persist in the effective m...

Pei Y, Qi K, Zhou Y, Xu L, Wang J, Deng X et al.

Multidrug-resistant (MDR) Gram-negative bacteria poses a significant public health risk due to its multidrug resistance mechanism. The discovery of novel antibiotic adjuvant to combat clinical superbugs is an urgent priority for addressing the antibiotic resistance crisis. Here, through checkerbo...

Gao Z, Hu Y, Zheng N, Wang Q, Xie C, Chen M et al.

Overcoming the blood-brain barrier (BBB) remains a pivotal challenge in central nervous system (CNS) drug development. Here, we present an active CNS-targeted strategy based on BBB endogenous transporters, specifically through the rational design of novel tacrine derivatives. This study pioneers ...

Lally JS, Crowley RJ, Mann K, Kline DM, Bunting AM

The gender composition of the physician workforce in the United States (US) is constantly evolving. This study aimed to determine how female physician representation has changed from 2014-2024 with attention to geographic and temporal trends.Data were obtained on US physicians from the Centers fo...

Cutarella L, Temprano AG, Tafi A, Mori M

The rapid spread of antimicrobial resistance (AMR) has relaunched Colistin A, a member of the polycationic polymyxin (PMBs) family, as a last resort option against infection by Gram-negative pathogens such as Pseudomonas aeruginosa. However, the presence of positively charged α,γ-Diam...

Kashi M, Chegini Z, Amiri SV, Arabestani M, Shariati A

Miyauchi S, Utsunomiya Y, Okamoto M, Akesaka K, Ono K, Hara Y et al.

We report the case of a 47-year-old woman with severe hypertriglyceridemia due to a homozygous APOA5 c.553G>T (p.Gly185Cys) mutation. She presented with markedly elevated triglyceride levels (TG, 1,047 mg/dL) that were unresponsive to lifestyle modifications. Lipoprotein fractionation revealed...

Naing SY, Severin J, Zomer A, Kuntaman K, Suandy I, Sunandar S et al.

Colistin is a last-resort antimicrobial used to treat infections caused by multidrug-resistant Gram-negative bacteria in humans. In Indonesia, widespread detection of colistin use and resistance in commensal Escherichia coli from poultry, particularly broilers, led to a national ban on its use in...

Chee SW, Zaki RA, Hng SY, Eg KP, Lee QY, de Bruyne JA et al.

The nebulization of antibiotics allows the delivery of high concentration of medication to the lungs without the systemic side-effects.We performed a systematic review and meta-analysis to determine the efficacy and safety of inhaled antibiotics in children with ventilator-associated pneumonia (V...

Qi Y, Wang S, Li Z, Yan X, Yang Y, Li B et al.

Calcium is an essential micronutrient commonly supplemented through diet or fortified products. This study aimed to develop efficient peptide‑calcium chelates from eggshell (ES) and eggshell membrane (ESM), agricultural by-products rich in proteins but with an inherently low calcium chelat...

Qin K, Li X, Wu X, Xie X, Xiang K, Zhou H et al.

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a promising therapy for ischemic cardiomyopathy, which is often secondary to hypertension but remain functionally immature. We investigated whether exosomes from human cardiac fibroblasts (hc-FB-EXOs) promote hiPSC-CMs mat...

Dong AJ, Berlin NL, Tsai TC

Xie M, Xie B, Huang L, Chen Y, Lai X, Yan M et al.

Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the primary indication for heart transplantation. The intricate and poorly elucidated pathogenesis of genetic DCM, coupled with the paucity of effective therapeutic options, imposes a substantial burden on both patients and thei...

Mousa WS, Abdeen EE, El-Gendy HF, Alsaadawy RM, Hana MM

Pseudomonas aeruginosa is a common pathogen of a wide range of nosocomial infections in humans, as well as foodborne illnesses. The current study focuses on the molecular genotyping of P. aeruginosa recovered from human, water, and food specimens. A total of 350 samples, fifty samples each from h...

Amegatcher G, Adu J, Arcton EW, Okine EN, Dankwah TK, Osei MM et al.

Gram-negative pathogens are notable causes of diverse human infections. This study determined the antibiotic sensitivity profile of clinical isolates of gram-negative bacteria to provide insights into high-priority pathogens that are potential threats to public health in Ghana. Gram-negative isol...

Aziz N, Pizer B, Parks C, Hennigan D, Mallucci C, Avula S et al.

Postoperative cerebellar mutism syndrome (pCMS) is a recognised complication following posterior fossa tumour (PFT) resection in children, marked by delayed-onset mutism or reduced speech with neurocognitive and motor deficits. Injury to proximal efferent cerebellar pathways is implicated. This s...

Xiao Y, Peng T, Li K, Zhao R, Wang Z, Zhang G et al.

Mucoid Pseudomonas aeruginosa is frequently isolated from patients with non-cystic fibrosis bronchiectasis (NCFB), yet the clinical and microbiological consequences of this phenotype remain unclear. In this retrospective study, we analyzed 66 patients with NCFB from whom P. aeruginosa was isolate...