CNTF Peptide Research

Diksha, Kumar A, Gaurav V, Mathuria YP, Gupta SK, Ghosh DK et al.

Growth arrest-specific 6 (GAS6) protein is required for cell survival through its role in TAM receptor signalling. Here, we investigate a novel autosomal recessive demyelinating disorder in a 9-year-old male presenting with progressive motor dysfunction, spasticity, seizures and cognitive decline...

Fedotcheva TA, Shimanovsky NL

The regulation of the synthesis of the nerve growth factor and other neurotrophins is one of the dynamically developing areas of pharmacotherapy of neurological and mental disorders. Despite a large number of studies of various ligands of neurotrophin receptors, only a few have reached clinical a...

Shirasath KR, Nakhate KT, Goyal SN, Awathale SN

Although transient receptor potential melastatin 3 (TRPM3) channels are primarily known for their role in spinal nociception, emerging evidence suggests their involvement in psychiatric conditions and central reward processing. Menopause, characterized by estrogen decline, induces neuroimmune act...

Abramian A, Damaskou A, Toonen RF, Verhage M

Human excitatory neurons programmed through neurogenin-2 (NGN2) overexpression are widely used to model brain disorders in vitro. Although growth factors (GFs) such as BDNF, GDNF, NT3 and CNTF are commonly included in differentiation protocols, their individual and combined effects on neuronal su...

Wang X, Li X, Yang D, Chen L, Li B, Liu B et al.

This study analyzed protein sequencing from rat samples, categorized into a control group (Chronic Constriction Injury, CCI) and test (treated with dracorhodin perchlorate, DP), The purpose of this study was to identify key target proteins of DP in the treatment of sciatica and elucidate its unde...

Rathod SS, Agrawal YO

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and neuroinflammation. Synaptic plasticity and neuroinflammation are hallmarks of AD, with their dysregulation forming a self-reinforcing cycle that aggravates neurodegen...

In Het Panhuis W, Thiemann E, van Dijk DMAH, Been B, Jarrett KE, Meurs A et al.

The chimeric cytokine IC7Fc conveys the metabolic signaling properties of the glycoprotein 130 receptor cytokines interleukin-6 and ciliary neurotrophic factor via membrane-bound signaling. IC7Fc was previously shown to slow the progression of type 2 diabetes mellitus, and here, we demonstrate it...

Infante-Tadeo S, Barber DL

The neurodegenerative disorder frontotemporal dementia (FTD) can be caused by a repeat expansion (GGGGCC; G4C2) in C9orf72. The function of wild-type C9orf72 and the mechanism by which the C9orf72-G4C2 expansion causes FTD, however, remain unresolved. Diverse disease models, including human brain...

Laplante V, Rousseau M, Terki S, Monsef LA, Najmanovich R, Lesage S et al.

Cardiotrophin-like cytokine factor 1 (CLCF1) is a cytokine of the IL6/IL12 superfamily with pro-neurotrophic and immune-modulating functions. Although the pro-neurotrophic activities of CLCF1 are mediated through the ciliary neurotrophic factor receptor (CNTFR), the α receptor chain of the ...

Quan R, Hou X, Zhang J, Chen Z, Liu W, Guo B et al.

Tissue injury presents a complex microenvironment with temporal pathological dynamics, necessitating precision therapeutic strategies. However, current interventions lack effective measures that precisely respond to and modulate the dynamic changes in the microenvironment. Herein, a biomaterial-d...

Pudewell S, Heuser J, Dorogobed I, Lipinski B, Tran THH, Metzenmacher P et al.

Although Interleukin (IL)-6-type cytokine signaling is critical for maintaining the body's homeostasis, aberrant signaling has been observed in numerous diseases including autoimmunity and cancer. Currently, all approved biologics that inhibit IL-6-type cytokines specifically target the key pro-i...

Ren X, Huang Q, Xie Z, Liu Z, Wei J, Zheng J et al.

Neuroinflammation microenvironment and retinal ganglion cell (RGC) apoptosis are two critical barriers to axonal regeneration following traumatic optic neuropathy (TON). To overcome these challenges, we developed an innovative dual drug delivery strategy utilizing oriented porous nanofiber (OF) a...

Kauper K, Nystuen A, Orecchio L, Gonzalez-Lopez E, Lee A, Duncan JL et al.

This retrospective analysis examined drug release levels and long-term function of revakinagene taroretcel-lwey (formerly known as NT-501), a ciliary neurotrophic factor (CNTF)‒releasing encapsulated cell therapy, following implant durations of 0.5 to 14.5 years in participants with retina...

Nair SV, Jaimon E, Adhikari A, Nikoloff J, Pfeffer SR

Parkinson's disease is characterized by loss of dopamine neurons that project to the dorsal striatum, and mutations in LRRK2 and GBA1 are the most common genetic causes of familial Parkinson's disease. Previously, we showed that pathogenic LRRK2 mutations inhibit primary cilia formation in rare i...

Chew EY, Gillies M, Jaffe GJ, Gaudric A, Egan C, Constable I et al.

Revakinagene taroretcel (NT-501) is an encapsulated cell therapy producing ciliary neurotrophic factor that slowed retinal degeneration in patients with macular telangiectasia type 2 (MacTel) in phase 2 trials.In NTMT-03-A and NTMT-03-B - identically designed phase 3, multicenter, randomized sham...

El-Boghdady NA, Elsayed EI, Samir A, Abdelmonem M

Multiple sclerosis (MS) is a chronic demyelinating and inflammatory neurodegenerative disease that impacts more than 2.8 million patients worldwide. Hydrogen sulfide (H2S) impairment and dysregulation are implicated in the pathogenesis of MS. The current study aims to explore the potential protec...

Nystuen A, Gonzalez-Lopez E, Kauper KA, Eade K, Aaberg TM

Neurotrophic factors are a family of proteins that promote the growth and survival of both developing and mature neurons. Extensive preclinical studies have demonstrated neuroprotective properties conferred by ciliary neurotrophic factor (CNTF) in a variety of neuron types across several species....

Amalakanti S, Arepalli KVR, Jillella JP

Guillain-Barré Syndrome (GBS) is an acute neuropathy characterized by varying prognoses. To identify predictive biomarkers, we conducted a prospective observational study involving 110 GBS patients. We focused on assessing the levels of two proteins associated with neurogeneration, namely CN...

Hoy SM

Revakinagene taroretcel (revakinagene taroretcel-lwey; ENCELTO™) is an encapsulated cell-based gene therapy containing 200,000-440,000 allogeneic retinal pigment epithelial (RPE) cells expressing recombinant human ciliary neurotrophic factor (rhCNTF). Available as a single-dose intravitrea...

Colleluori G, Viola V, Bathina S, Armamento-Villareal R, Qualls C, Giordano A et al.

Obesity exacerbates age-related changes in metabolic and physical function. The effect of distinct exercise modalities combined with diet-induced weight loss on insulin secretion in older adults with obesity and frailty is unknown, and the potential mediators of the metabolic and functional impro...