Chonluten Research

Koutsogiannaki S, Hou L, Alhamdan F, Mastali M, Murray C, Van Eyk J et al.

CD11c (integrin αX) is one of the β2 integrin members traditionally recognized as a dendritic cell marker. It forms the CD11c/CD18 heterodimer-also known as complement receptor 4 (CR4)-and mediates ligand binding to complement fragments, fibrinogen, and intercellular adhesion molecule...

Morikawa K, Takashima Y, Oki M, Tsuzuku A, Murakami S, Minami D et al.

There are no prospective studies to estimate whether cytology specimens can replace tissue samples using lung cancer gene panel analysis. We evaluated the success rate of gene panel testing and nucleic acid yield and quality when using cytology specimens for lung cancer over tissue specimens.In t...

Panfilova A, Zubareva T, Mironova E, Mazzoccoli G, Marasco MGP, Balazovskaia S et al.

Research in the field of mitochondrial biomarkers plays an important role in understanding the processes of cellular aging. Mitochondria are not only the energy centers of the cell, but also key regulators of signaling within the cell. They significantly affect the life and function of the cell. ...

Maejima Y, Yokota S, Yamachi M, Hidema S, Ono T, Taira S et al.

While it is well-documented that plasma oxytocin (OXT) levels decline with age, the underlying mechanisms remain elusive. This study aimed to elucidate the physiological mechanisms contributing to this age-related decrease in plasma OXT and the possible use of OXT supplementation on improving age...

Han J, Zhang M, Ge J, Ji Z, Zhao J, Hu Y et al.

8-oxoguanine (8-oxoGua) is one of the most frequent forms of oxidative DNA base lesions, repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) via base excision repair (BER) pathway to maintain genome fidelity. The human allelic variant hOGG1S326C, prevalent in Caucasians and Asians, has been regarde...

Yanagihara T, Hata K, Matsubara K, Kunimura K, Suzuki K, Tsubouchi K et al.

Background: Lung malignancies, including cancerous lymphangitis and lymphomas, can mimic interstitial lung diseases like cryptogenic organizing pneumonia (COP) on imaging, leading to diagnostic delays. We aimed to identify potential biomarkers to distinguish between these conditions. Methods: We ...

Ishii Y, Shiota A, Takao T, Yamamoto N, Ogawa T, Jo A et al.

Takao T, Matsui A, Kikutake C, Kan-O K, Inoue A, Suyama M et al.

The root of asthma can be linked to early life, with prenatal environments influencing risk. We investigate the effects of maternal asthma on the offspring's lungs during fetal and adult life. Adult offspring of asthmatic mothers show an increase in lung group 2 innate lymphoid cell (ILC2) number...

Wang J, Li C, Han J, Xue Y, Zheng X, Wang R et al.

ROS cause multiple forms of DNA damage, and among them, 8-oxoguanine (8-oxoGua), an oxidized product of guanine, is one of the most abundant. If left unrepaired, 8-oxoGua may pair with A instead of C, leading to a mutation of G: C to T: A during DNA replication. 8-Oxoguanine DNA glycosylase 1 (OG...

Hosono Y, Tomiyasu N, Kasai H, Ishikawa E, Takahashi M, Imamura A et al.

Invariant natural killer T (iNKT) cells are unconventional T cells recognizing lipid antigens in a CD1d-restricted manner. Among these lipid antigens, α-galactosylceramide (α-GalCer), which was originally identified in marine sponges, is the most potent antigen. Although the presence ...

Zubareva T, Mironova E, Panfilova A, Krylova Y, Mazzoccoli G, Marasco MGP et al.

This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins are discussed as potential therapeutic tar...

Guryanova SV

Microorganisms colonize all barrier tissues and are present on the skin and all mucous membranes from birth. Bacteria have many ways of influencing the host organism, including activation of innate immunity receptors by pathogen-associated molecular patterns and synthesis of various chemical comp...

Torta F, Hoffmann N, Burla B, Alecu I, Arita M, Bamba T et al.

In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species in the NIST (National Institute of Standards and Technology) human bloo...

Hikasa H, Kawahara K, Inui M, Yasuki Y, Yamashita K, Otsubo K et al.

The activation of yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ) has been implicated in both regeneration and tumorigenesis, thus representing a double-edged sword in tissue homeostasis. However, how the activity of YAP1/TAZ is regulated or what lead...

Kuzminov OM, Musienko SK, Pushkin AS, Davydova EP, Evnevich YV, Saginbaev UR et al.

Research on the condition of the lungs in senile people is an urgent task. This is due to the fact that degenerative or age-associated changes in the respiratory system play an important role in the formation of senile asthenia syndrome and a decrease in the age-related viability of the body as a...

Igami K, Kittaka H, Yagi M, Gotoh K, Matsushima Y, Ide T et al.

Mitochondrial transcription factor A, TFAM, is essential for mitochondrial function. We examined the effects of overexpressing the TFAM gene in mice. Two types of transgenic mice were created: TFAM heterozygous (TFAM Tg) and homozygous (TFAM Tg/Tg) mice. TFAM Tg/Tg mice were smaller and leaner no...

Yanagihara T, Hata K, Matsubara K, Kunimura K, Suzuki K, Tsubouchi K et al.

Anticancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is Pneumocystis jirovecii pneumonia (PCP), which can cause severe respiratory complications an...

Sorokin M, Markin K, Trufanov A, Bocharova M, Tarumov D, Krasichkov A et al.

Factors such as coronavirus neurotropism, which is associated with a massive increase in pro-inflammatory molecules and neuroglial reactivity, along with experiences of intensive therapy wards, fears of pandemic, and social restrictions, are pointed out to contribute to the occurrence of neuropsy...

Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T et al.

Nicotinamide phosphoribosyltransferase (NAMPT) plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and p...

Nishiyama A, Shimizu M, Narita T, Kodera N, Ozeki Y, Yokoyama A et al.

Mycobacteria are the major human pathogens with the capacity to become dormant persisters. Mycobacterial DNA-binding protein 1 (MDP1), an abundant histone-like protein in dormant mycobacteria, induces dormancy phenotypes, e.g. chromosome compaction and growth suppression. For these functions, the...