Cholecystokinin Research

Huang K, Cai H, Hong Y, Wu L, Bao J, Jiang C et al.

Osteoarthritis (OA) involves progressive cartilage degradation, and the extracellular matrix (ECM) regulates chondrocyte behavior. In OA, ECM stiffening, driven by age-related matrix changes and mechanical joint injuries, contributes to cartilage damage. Although RhoA/ROCK and ERK1/2 signaling pa...

Wu L, Chen M, Chai J, Tang Y, Xu Q

To investigate the inhibitory effect of luteolin on proliferative vitreoretinopathy (PVR) and explore its potential mechanism.Human retinal pigment epithelial ARPE-19 cells were treated with luteolin (0-50 μM) to assess its effects on cell viability, migration, and TGF-β2-induced...

Yang C, Xia J, Zhao L, Tao J, Li D, Zhu R et al.

In recent years, bladder defect repair has emerged as a critical issue in urological tissue engineering. Traditional treatment methods, such as autologous tissue transplantation and synthetic material repair, are limited by factors such as scarce donor sources, immune rejection, and postoperative...

Zhang C, Wang Y, Tang H, Wu Z, Jia S, Wu J et al.

 To elucidate the therapeutic mechanism of polydatin against lung ischemia-reperfusion injury (LIRI), this study adopted an integrated strategy combining network pharmacology with experimental verification.Potential targets of polydatin were retrieved from TCMSP, PubChem, SwissTargetPredicti...

Liang HH, Jia LL, Tang K, Xue R, Nie RR, Chen JN et al.

Colorectal cancer (CRC) exhibits high mortality due to tumor cell dissemination. Surgical resection combined with chemotherapy is the primary treatment, but chemoresistance often limits its efficacy against metastasis. Cuproptosis, a novel cell death mechanism regulating mitochondrial and lipid m...

Nie R, Zhou H, Chen L, Quan H, Zhang Y, Lin Z et al.

Reprogramming of lipid metabolism is a hallmark of malignant tumors, and targeting key enzymes in lipid metabolism has emerged as a critical strategy to inhibit tumor progression. Sterol regulatory element-binding protein 1 (SREBP1), a master regulator of lipid biosynthesis, drives lipid metaboli...

Hu Y, Hu K, Liang J, Zhang X, Li H, Wu J et al.

Hair loss, a multifactorial disorder characterized by follicular miniaturization and excessive shedding, significantly impairs psychological well-being and quality of life. Cyperus rotundus rhizome (CR), a traditional Chinese medicine used for various ailments, has not been evaluated for efficacy...

Gao P, Zhang C, Zhong S, Wei J, Ma H

Neurotensin receptor 1 (NTSR1) is linked with poor prognosis in many tumors, including gastric cancer (GC). However, the exact mechanism by which NTSR1 affects GC anoikis in GC has not yet been clarified. Therefore, this project aimed to figure out the specific mechanism by which NTSR1 participat...

Guo Z, Hao H, Deng X, Jiao Y, Dong B, Xue D et al.

Triple-negative breast cancer (TNBC) has a poor clinical prognosis and shows resistance to traditional treatments. Ferroptosis is a potential therapeutic strategy for TNBC. Although dandelion extract has demonstrated anti-tumor effects against TNBC, its role in regulating ferroptosis has not been...

Liu D, Peng Z, Yu W, Liao J, Wei J, Yang J et al.

Gushu pills (GSW), a traditional Chinese medicine formulation, have demonstrated clinical efficacy in treating bone metabolic disorders, including osteoarthritis (OA). However, the underlying molecular mechanisms remain poorly understood. This study aimed to investigate the therapeutic effects of...

Yao J, Li F, Hua X, Lu M

Non-alcoholic fatty liver disease (NAFLD), a chronic metabolic disorder characterized by ectopic lipid deposition in hepatocytes, currently lacks evidence-based pharmacotherapies, rendering probiotic-based strategies-particularly those utilizing Lactobacillus rhamnosus (LR)-a promising therapeuti...

Pan Y, Sun R, Thomas ER, Pan S, Yang L, Wang W et al.

To elucidate the mechanism of Schizonepeta tenuifolia-Diosmetin in acne treatment using an integrated approach combining network pharmacology, molecular dynamics simulation, and experimental validation. Acne-related expression datasets were acquired from GEO, with differentially expressed genes (...

Feng C, Yang C, Gao W, Liu Y, Wei J, Shen C et al.

 This study aims to combine in vitro experiments with cell metabonomics used to explore the anti-colorectal cancer effect of Dahuang Mudan Decoction drug-containing serum.CCK-8, colony formation assay, and wound healing were utilized to evaluate the effects of DHMDD drug-containing serum on ...

Liu X

Exosomes are essential mediators of intercellular communication and, as such, have attracted considerable interest in regenerative medicine. Aantler stem cells (ASCs) have become the central candidate in the field of the periodic regeneration of the deer antlers-the only mammalian organ that can ...

Zhou R, Gao Y, Shang B, He J, Fang M, Cao Y et al.

Mangiferin (Mng) is a polyphenolic natural flavanthrone known for antioxidant, antiviral, immunomodulatory, and antibacterial properties. In center nervous system, excessive Glutamate (Glu) can lead to oxidative stress by elevating ROS generation and subsequently undermining the antioxidant defen...

Nanthakumar P, Law JX, Ng SF

Long COVID has been increasingly linked to chronic inflammatory skin conditions driven by cytokine overproduction. Topical tacrolimus, a calcineurin inhibitor, is commonly used to manage such conditions due to its immunosuppressive properties. However, due to poor dermal penetration, tacrolimus o...

Shang Y, Peng YG, Wang Y, Huo XK, Zhang HL, Hao TN et al.

Liver fibrosis is a critical pathological stage in the progression of chronic liver diseases, yet safe and effective antifibrotic agents remain lacking. Anwulignan (Anwu), a lignan component derived from the traditional hepatoprotective herb Schisandra chinensis (Turcz.) Baill., possesses hepatop...

Shen J, Zhao Z, Li Z, Wang R

Explore the causes and mechanisms of bladder cancer-induced Cardiovascular diseases (CVD) death.We acquired bladder cancer patient data from the SEER database to evaluate CVD death risk. Cross-WGCNA was employed to identify comorbidity genes linking bladder cancer and heart failure. Functional ph...

Zhang H, Hao W, Chang H, Bie Y, Sun X

Ischemic stroke is a prevalent neurological disorder, characterized by elevated mortality and significant long-term disability. Oxidative stress damage is an important pathological process that occurs after brain ischemia/reperfusion (I/R), in which the long non-coding RNA death-associated protei...

Zhong Y, Wei L, Xue R

Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss and with limited effective therapies. Oxidative stress, driven by disrupted redox balance and excessive reactive oxygen species (ROS), is believed to be a key pathogenic driver....