Chlorotoxin Research

Batty LM, Huynh M, Webster KE, Vassileff N, Spiers JG, Klemm HJ et al.

The risk of posttraumatic arthritis is elevated after anterior cruciate ligament (ACL) injury, and this can influence follow-up patient-reported outcome measures (PROMs). Biomarkers of chondral and matrix metabolism may represent a means of quantitatively evaluating the posttraumatic arthritis pa...

Barry H, Scillia L, Gaubert A, Amrane S, Vialet B, Bégu D et al.

Antimicrobial resistance is a current public health challenge. In line with the new One Health policy and the World Health Organization priority pathogen list, this study explores antisense oligonucleotides targeting ß-lactamase CTX-M-15, responsible for one of the most prevalent mechanisms ...

Chomérat N, Rose N, Lavenu L, Díaz-Asencio L, Belmont C, Hollanda S et al.

Benthic dinoflagellates associated with human ciguatera poisoning are present in the Indian Ocean and species such as Fukuyoa (formerly Gambierdiscus) yasumotoi, G. toxicus and G. belizeanus have been reported since the mid 90s. Even though, very little information is available concerning the occ...

Salamunes ACC, Williams NI, Ricker EA, Mallinson RJ, Koltun KJ, De Souza MJ et al.

To investigate whether experiencing ≥2 consecutive menstrual cycles of <36 days improved bone mineral density (BMD) and bone turnover markers in response to increased energy intake in young exercising women with oligo-amenorrhea.The REFUEL study was a 12-month RCT designed to inc...

Aoki K, Imaizumi K, Mano Y, Tateda K, Furuya N

We report the complete genome sequence of a carbapenem-resistant Enterobacter hormaechei ST133 strain isolated from a clinical stool sample at a hospital in Tokyo, Japan, in 2022. This isolate harbors a novel conjugative IncHI2-pST1 plasmid carrying blaIMP-6. Additionally, this plasmid co-carries...

Ghorbani Tajani A, Hamidi A, Sharma A, Sylejmani D, Gorçaj E, Hashani G et al.

We report the draft genome of multidrug-resistant Escherichia coli UA1 from Kosovo retail chicken liver, revealing ARGs (blaEC-18, blaCTX-M-55, and dfrA36), virulence genes, and plasmids. Assembled into 86 contigs and 214 scaffolds, it highlights antimicrobial resistance dissemination in the food...

Heider S, Gohlke S, Kuxhaus O, Haueise T, Stefan N, Birkenfeld AL et al.

Bone marrow adipose tissue (BMAT) has been linked to negative bone health outcomes and a high level of bone marrow adipocyte accumulation is observed during aging and in individuals with diabetes and obesity. This study explores the relationships between BMAT, age, metabolic health and the impact...

Takase H, Chikazawa M, Noguchi M, Ichi I, Takahashi Y, Yamauchi Y et al.

Skeletal muscle possesses a remarkable capacity for regeneration, which is largely orchestrated by muscle satellite cells (MuSCs), a population of tissue-resident stem cells. Upon injury, these cells sense cues from their niche, transition from quiescence to activation, and subsequently undergo p...

Qin X, Lian YE, Tang H, Chai X, Gao Y, Ma Y et al.

Bone loss is a serious complication of mechanical unloading, such as that experienced during spaceflight or prolonged bed rest, and represents a significant clinical concern. Although the gut-bone axis has been implicated in bone homeostasis, its role under unloading conditions remains underexplo...

Chen YC, Kao CY, Chen CC, Tang HJ, Chang TH

Multidrug-resistant (MDR) Klebsiella pneumoniae outbreaks in pediatric intensive care units (PICUs) pose serious risks to vulnerable patients. We report a one-year cluster of MDR K. pneumoniae in a PICU, along with the genetic relatedness, antimicrobial resistance profiles, and resistance mechani...

de Almeida CM, Lopes KG, da Costa Tavares Bezerra M, Leal PRF, Bouskela E, da Gama EMF et al.

The effects of metabolic and bariatric surgery on bone health still require further investigation. Osteometabolism biomarkers, bone microarchitecture (BM), and mineral density (BMD) of patients who have undergone Roux-en-Y gastric bypass (RYGB) within 2-5 years from surgery were compared t...

Biver E, Body JJ, Sachdeva A, Študentová H, Nagy Z, Kun A et al.

Denosumab is a monoclonal antibody targeting the receptor activator of nuclear factor kappa-b ligand widely used for the prevention of skeletal-related events in patients with bone metastases. This Phase 1 randomized, double-blind, two-arm, parallel-group study assessed the equivalence in pharmac...

Eccles S, Vanyai HK, Bergamasco MI, Malelang S, Pehlivanoglu H, Garnham AL et al.

Pathogenic variants in one allele of the KAT6A gene encoding the histone acetyltransferase KAT6A (MOZ, MYST3) cause Arboleda-Tham syndrome (ARTHS), characterised by developmental delay, cognitive impairment, and autism-like behaviours. As histone acetylation is reversible, and brain development c...

Kamr A, Fortin-Trahan R, Arroyo LG, Hostnik LD, Gomez DE, Toribio RE et al.

Hypocalcemia is frequent in horses with colitis. Information on serum parathyroid hormone (PTH) concentrations and its association with bone turnover biomarkers in horses with colitis is lacking. We aimed to determine the association between serum bone resorption biomarkers (C-terminal telopeptid...

Huang WH, Tsai PY, Chen CL, Huang CH

Polysaccharides derived from macroalgae exhibit potent immunomodulatory and gut-regulatory activities; however, comprehensive comparisons of their differential bioactivities remain scarce. This study systematically evaluated the immunomodulatory potential of structurally distinct polysaccharides ...

Moutombi Ditombi BC, Manomba Boulingui C, Mbang Nguema OA, Mihindou CJ, Pongui Ngondza B, Ndong Ngomo JM et al.

Malaria and HIV remain major public health challenges in sub-Saharan Africa. This study described the spectrum of malaria in people living with HIV (PLHIV) and HIV-negative adults in Gabon, where both diseases are endemic.A cross-sectional study was conducted at the Centre Hospitalier Universitai...

Natukunda E, Mwaka E, Szubert AJ, Bamford A, Doerholt K, Wandera C et al.

Long-term impact of antiretroviral therapy (ART) on bone health in children living with HIV (CLWH) remains uncertain. We aimed to determine associations of change in bone mineral density (BMD) among CLWH in Uganda in a 2-year prospective sub-study in the CHAPAS-4 randomized trial (ISRCTN22964075)...

Delgado-Suarez EJ, Puente-Cruz AL, Sánchez-Zamorano LM, Rubio-Lozano MS, Ballesteros-Nova NE, Hernández-Pérez CF et al.

Global dissemination of emergent multidrug-resistant (MDR) Salmonella Infantis (ESI) is of great public health concern. ESI exhibits increased virulence and MDR phenotypes, features conferred by a conjugative megaplasmid (pESI-like). In Mexico, the potential circulation of ESI clones has been ove...

Qin Y, Zhao L, Mu R, Wang H, Yang D, Su Z et al.

The clinical utility of serum bone turnover markers (BTMs) in managing osteoporosis in the elderly is constrained by the absence of personalized reference intervals (prRI) based on biological variation (BV).This longitudinal study tracked monthly serum levels of β-CTX, PINP, OC, PTH, a...

Ndiaye I, Sow O, Cissé A, Sambe Ba B, Thiam F, Boye MM et al.

Carbapenem resistant Acinetobacter baumannii (CRAB) is considered a top priority pathogen by the World Health Organization and is also considered a leading cause of healthcare-associated infections (HAIs). This study aimed to investigate antimicrobial resistance (AMR) patterns and perform compreh...