CGRP Research

Lipton RB, Dodick DW, Davis L, Nahas SJ, Goadsby PJ

To assess the role of small-molecule calcitonin gene-related peptide receptor antagonists (gepants) in the acute treatment of migraine, particularly in relation to triptan treatments.Triptans have established efficacy and are widely prescribed for the acute treatment of migraine. However, triptan...

Wang J, Wang F, Liu J, Xiao Y, Li Z, Liu X et al.

Chemotactic migration of peritendinous nerves is essential for tendon regeneration, yet the underlying neuroelectrical mechanisms remain unclear. Here, we identify an electrically responsive yes-associated protein 1 (YAP1)/phosphorylated signal transducer and activator of transcription 3 (pSTAT3)...

Xu S, Song W, Wang Y, Zhao Y

The objective of this study was to investigate the potential association between the use of calcitonin gene-related peptide (CGRP) antagonists and the reporting of cardiac adverse events (cAEs) by analyzing data from the US Food and Drug Administration Adverse Event Reporting System (FAERS). CGRP...

Lansbergen CS, Fronczek R, Wilbrink LA, Cohen SP, de Vos CC, Huygen FJPM et al.

Rattanawong W, Hiransuthikul A, Anukoolwittaya P, Pongpitakmetha T, Thanprasertsuk S, Manohararaj N et al.

Bou Malhab FM, Jabbour SA, Defronzo R, Nemr R

The pancreas is innervated by a complex network including vagal, sympathetic, and spinal sensory pathways but recent studies suggest that the trigeminal system, known for its role in sensory perception, may also contribute to pancreatic innervation.This review explores the hypothesis that the tri...

Zhang X, Bao H, Hu J, Ren W, He Z, Yu-Taeger L et al.

Chronic neuroinflammation and dysfunction of the neuro-glial-vascular unit (NGVU) are central mechanisms driving the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Neuropeptides, as key regulatory signaling molecules in the central nervous system (CNS), bin...

Fitzek MP, Kleist P, Handtmann C, Overeem LH, Hoehne CL, Lange KS et al.

Oxytocin has been implicated in migraine pathophysiology through its roles in pain modulation and vascular regulation. Its receptors are present in migraine-related brain regions and cerebral vessels and interact with key migraine mediators such as calcitonin gene-related peptide (CGRP). Declinin...

Hassan A, Elmazny A, Elgenidi A, Dahshan A, Abu-Arafeh I, Magdy R et al.

BackgroundHigh-quality research studies on therapeutic approaches for migraine management in pediatrics are scarce. Therefore, we conducted a systematic review of current clinical practice guidelines for the diagnosis and management of migraine in children and adolescents to identify areas of con...

Chu H, Pan J, Huang C

This study aimed to observe the efficacy and safety of rimegepant, a small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist, for the acute treatment of vestibular migraine (VM).Patients meeting the diagnostic criteria for VM or probable VM received rimegepant 75 mg for acu...

Imai S, Ihara K, Takahashi N, Ohtani S, Watanabe N, Iba C et al.

Capes DE, Slone VK, Winchester DK, Salazar J, Opoku PAD, Li Y et al.

Macrophage and microglial densities around spinal cord injury (SCI) lesions remain chronically elevated. The influence of non-resolving neuroinflammation on ongoing functions, repair, or regeneration after SCI is not well understood. We administered a 2-week treatment of the CSF1-R antagonist, PL...

Franz J, Ng TF, Gupta S, Wilson MR, Fini ME, Masli S et al.

Chronic ocular surface disease (OSD) is characterized by corneal epitheliopathy, reduced barrier function and loss of nerves, accompanied by persistent inflammation. Current treatments offer limited relief and there is no approved therapy that promotes neurosensory regeneration in OSD. Here, we t...

Su Y, Wang H, Liu W, Chen K, Min Y, Zhu J et al.

The skeletal interoception system that orchestrates bone homeostasis and regeneration through a coordinated "afferent-integration-efferent" reflex arc has been overlooked in bone tissue engineering. The dorsal root ganglion (DRG) neurons constitute the hubs of this system. Moreover, beyond their ...

Weng X, Yang J, Ma W, Li L

The inability of damaged neurons to regenerate poses a significant challenge in the repair of peripheral nerve injuries. Exogenous cell therapies, such as those involving neural stem cells or induced pluripotent stem cells, are limited by immune rejection and ethical concerns. Somatic cells offer...

Abdelwahed OM, Aboulhoda BE, Gouda SAA, Shoukry T, Rashed L, Alkaffas M et al.

The spleen plays a crucial role during inflammation through its resident macrophages, which may be influenced by modulations in neurochemical levels inside the spleen. Transient receptor potential vanilloid 1 (TRPV1) was reported to modulate the immune responses; however, its role in the spleen r...

McIlvried LA, Matos AAM, Krane RS, Eskew KT, LeGrande T, Atherton MA et al.

Peripheral sensory nerves are thought to play a role in solid tumor growth, particularly in oral squamous cell carcinoma (OSCC); however, the link between pain and immunosuppression remains unresolved. Here, we find an inverse relationship between OSCC-associated pain by way of calcitonin gene-re...

Iannone LF, Piella EM, Montisano DA, Fasano C, Sebastianelli G, Coppola G et al.

AimThe TACHIS study (from the ancient Greek adjective "tachýs" meaning rapid) aimed to evaluate eptinezumab effectiveness and tolerability in routine clinical practice, integrating patient-reported outcomes and use of International Headache Society (IHS)-endorsed categories of migraine contr...

Graves KS, To J, Paige H, Kennedy AG, Sprouse-Blum AS, Devine D et al.

To explore the safety and effectiveness of using two preventive calcitonin gene-related peptide (CGRP) antagonists in patients with chronic migraine. Although the literature supports concurrent use of CGRP antagonists for acute and preventive treatment of chronic migraine, it is unknown whether t...

Polakovičová S, Varga I, Filová B, Sallicandro L, Voller J, Fioretti B et al.

Although Merkel cells (MCs) are well-established mechanoreceptors in human skin, their function within the vaginal epithelium remains undefined. The aim of the present histological study was to investigate whether MCs located in the stratified epithelium of the anterior wall of the human vagina e...