Cetrorelix Research

Hammond O, El-Sheikh O, Saad RM, Shetty P, Papakonstantinou E, Kastora SL et al.

Aberrant vascular endothelial growth factor (VEGF)-driven angiogenesis is central to the establishment and persistence of endometriosis. Although numerous anti-angiogenic compounds have been tested, evidence remains fragmented, and no comparative framework guides the selection of agents compatibl...

Wang A, Yan Y, Jiang Y, Guan Y, Wen Z, Zhou S et al.

Chlorpyrifos (CPF), a commonly applied organophosphate insecticide, is known to disrupt the endocrine systems of aquatic species. However, further research is required to elucidate the molecular mechanisms involved in the reproductive toxicity of fish. In the present study, zebrafish were exposed...

Alabi C, Kastora S, Atik Y, Sherlock K, Vaughan E, Balachandren N et al.

Suppression of an LH surge is fundamental to successful oocyte retrieval after controlled ovarian stimulation. This study evaluates the efficacy and cost-effectiveness of progestin-primed ovarian stimulation (PPOS) using oral medroxyprogesterone acetate in fertility preservation cycles. The desig...

Zhang N, Liu Y, Zhang X, Xie M, Zhang Y, Hua K et al.

Epithelial ovarian cancer (EOC) has a dismal prognosis, and recent therapeutic advancements have been limited. The aim of our study was to clarify the role and mechanism of cetrorelix in EOC apoptosis and to evaluate the clinical relevance of GnRHR, AKT, and FOXO1 in EOC patients.Apoptosis was as...

Farmer DR, Leonardi CEP, Adams GP, Campbell J, Oliveira JLO, Singh J et al.

To determine the effects of a GnRH antagonist on ovarian function in cattle, we tested the hypotheses that cetrorelix will 1) cause regression of the extant dominant follicle by altering gonadotrophin secretion and 2) induce a new follicular wave emergence at a consistent time after treatment. In...

Singh J, Munteanu M, Shakeel MA, Adams GP

The objectives of the study were to determine the effects of dose (double vs single) of a GnRH antagonist (Cetrorelix) and follicular status (known status vs random status) on ovarian follicular wave synchrony. In Experiment 1, we tested the hypotheses that treatment of alpacas with two doses of ...

Buzcu H, Yüksel M, Kırmızıkan S, Çikler E, Karakoyun B

Phoenixin (PNX), first discovered in the rat hypothalamus, was initially identified as a reproductive peptide. PNX-14 (14 amino acid isoform) has also been shown to function in cardiovascular regulation, neuroprotection, glucose metabolism, appetite, anxiety, and memory. We aimed to investigate t...

Tafazzoli Mehrjardi S, Tafaghodi M, Malek S, Yari D, Mohammadpour AH, Kamali H et al.

Nasal sprays are extensively researched due to their rapid absorption, high bioavailability, and low side effects. Lipid liquid crystal nanoparticles (LLCNs) are being considered as potential carriers for intranasal delivery. LLCs loaded with cetrorelix (GnRH antagonist) were utilized for intrana...

Rahman NA, Chrusciel M, Ponikwicka-Tyszko D, Pulawska-Moon K, Doroszko M, Stelmaszewska J et al.

Extragonadal follicle-stimulating hormone (FSH) receptor (FSHR) expression in various cancers and their endothelial vessel cells has highlighted novel opportunities for targeted FSHR therapy.We investigated the specificity/cytotoxicity of Phor21 fusion lytic peptide, conjugated to 12 different FS...

Aluri K, Basavoju S, Rangisetty JB, Pullagurla MR, Pitta BR

In the synthesis of cetrorelix via solid-phase peptide synthesis (SPPS) employing the Fmoc strategy, the racemization of L-arginine and L-serine was effectively minimized to below 0.5%. This reduction was achieved using the coupling agent HATU, the additive HOBt or HOAt, and the base TMP. Racemiz...

Peng X, Lv X, Li P, Li Y, Hu Y, Zhang Y et al.

This study aimed to compare the safety, efficacy, and clinical predictors of live birth outcomes between cetrorelix and ganirelix in GnRH antagonist protocols during controlled ovarian stimulation.In this retrospective cohort study conducted at a reproductive medicine center (June 2019-June 2022)...

Rahman NA, Chrusciel M, Ponikwicka-Tyszko D, Pulawska-Moon K, Stelmaszewska J, Doroszko M et al.

The follicle stimulating hormone (FSH) receptor (FSHR), is expressed primarily in the gonads, also found in ovarian and prostate cancers, and in tumor vessel endothelial cells. We investigated the potential of a targeted cytotoxic approach using Hecate-FSHβ, a conjugate derived from a lytic...

Aldarsooni M, Alfarah M, Albohammod F, Al-Jaroudi D

A premature surge in luteinizing hormone (LH) during ovarian stimulation cycles between 12 and 25% has been commonly reported. However, there is still a lack of consensus on whether premature LH surge affects pregnancy outcomes.This study aimed to evaluate the effect of premature LH surge on preg...

Souza MM, Souza MDCB, Antunes RA, Barbeitas AL, Raupp VA, Souza ALBM et al.

To evaluate Dydrogesterone's effectiveness in PPOS protocols for IVF/ICSI or oocyte cryopreservation, focusing on LH surge suppression and metaphase II oocyte yield.A retrospective, comparative, single-center study of 550 IVF/ICSI and 186 oocyte cryopreservation cycles was conducted from January ...

Patel S, Saxena B, Mehta P, Niazi SK

Overexpression of the gonadotropin-releasing hormone receptor (GnRH-R) plays a vital role in the advancement of reproductive malignancies such as ovarian, endometrial, and prostate cancer. Peptidomimetic GnRH antagonists are a substantial therapeutic development, providing fast and reversible sup...

Sánchez Martín MJ, Huerga López C, Cristóbal García I, Cristóbal Quevedo I

Uterine fibroids are the most common pelvic tumors in women, representing the primary indication of hysterectomy. Gonadotropin-releasing hormone (GnRH) antagonists represent a new therapeutic option for premenopausal women. The aim of this review is to evaluate the efficacy and safety of GnRH ant...

Handa M, Takiuchi T, Kawaguchi S, Ohara Y, Doshida M, Takeuchi T et al.

The judicious selection of ovulation inhibitors in ovarian stimulation protocols is crucial for the success of assisted reproductive technology (ART). Herein, we investigate the dose-dependent effects of chlormadinone acetate (CMA) and cetrorelix, two distinct ovulation inhibitors, on oocyte matu...

Desaulniers AT, Ross CE, Cederberg RA, Lovercamp KW, Lents CA, White BR et al.

The second form of gonadotropin-releasing hormone (GnRH-II) and its receptor (GnRHR-II) are abundantly produced within the porcine testis and immunolocalize within the seminiferous tubules, suggesting a role in spermatogenesis and/or sperm function. The objective of this study was to quantify GnR...

Wang D, Zhang M, Wang WS, Chu W, Zhai J, Sun Y et al.

Polycystic ovary syndrome (PCOS) is the predominant cause of subfertility in reproductive-aged women; however, its pathophysiology remains unknown. Neurotensin (NTS) is a member of the gut-brain peptide family and is involved in ovulation; its relationship with PCOS is unclear. Here, we found tha...

Flores VA, Sahin C, Taylor HS

To use murine avatars for studying human endometriotic lesion response to 2 different hormonal regimens to determine whether progesterone receptor (PR) can prospectively predict response to progestin-based therapy. Endometriosis is a chronic gynecologic disease afflicting 1-in-10 reproductive-age...