Cerebrolysin Research

Khatkova SE, Pavlyuchenkova OS, Golovanova AV, Larin AS

This report presents a clinical case of a 39-year-old patient with severe right-sided hemiparesis and complex motor aphasia in the late recovery phase of ischemic stroke (IS). Alongside comprehensive physical rehabilitation and speech therapy sessions, the patient received several courses of intr...

Kalinin MN, Khasanova DR

The optimal timing of anticoagulation resumption after acute ischemic stroke remains uncertain, particularly in patients at elevated risk of hemorrhagic transformation (HT). Although Cerebrolysin reduces HT incidence, its influence on dynamic HT risk and the safe anticoagulation window remains un...

González JDSR, Tapia A

Multimodal treatment of patients with a brain tumor primarily involves microsurgical excision, ideally radical, or at least subtotal resection. Tumors in deep or inaccessible locations may require biopsy followed by adjuvant therapy with chemotherapy, radiotherapy, or radiosurgery. Beyond control...

Alexandrova EG, Abakumova TR, Ziganshina LE

ObjectiveTo analyse regulatory positions and drug policies of the Commonwealth of Independent States (CIS), compared to those of the EU, UK, USA i of the nootropics, used in Russia for Alzheimer's disease.MethodsWe searched E-library to reveal the list of nootropics used and studied in Russia for...

Aguilar-Hernández L, Flores-Gómez GD, Nacher J, Morales-Medina JC, Flores G

Aging is associated with progressive synaptic deterioration and cognitive decline; however, therapeutic strategies capable of restoring both structural and functional deficits remain limited. This study evaluated the effects of aging on dendritic spine dynamics and recognition memory across multi...

Schlager P, Grgac I, Herzer G, Trimmel H

Severe traumatic brain injury (sTBI) remains a major cause of long-term disability and mortality worldwide. Beyond the initial mechanical damage, a cascade of secondary injuries involving neuroinflammation, oxidative stress, and excitotoxicity exacerbates neural dysfunction. Neuroprotective agent...

Livinț-Popa L, Chelaru VF, Chertic-Dăbală D, Chira D, Verișezan-Roșu O, Dăbală V et al.

Traumatic brain injury (TBI) is a leading cause of disability and death. Both repetitive transcranial magnetic stimulation (rTMS) and Cerebrolysin (CRB) are promising therapies regulating neural plasticity. This study aimed to assess the changes in resting-state brain activity following CRB, rTMS...

Rockenstein E, Ubhi K, Trejo M, Mante M, Patrick C, Adame A et al.

Ribó M, Staszewski J, Zeiler SR, Michalak S, El Bassiouny A, Gongora-Rivera F et al.

This article provides perspectives on the use of Cerebrolysin as an adjunct treatment to reperfusion therapy in acute ischemic stroke (AIS). In the evolving landscape of AIS reperfusion therapy, we hypothesize that adjunctive cerebroprotective therapy, such as Cerebrolysin, is likely to further i...

Hosseini L, Abolhasanpour N, Seyedaghamiri F, Hassanzadeh P, Shahabi P, Mafikandi V et al.

Schizophrenia is known as a complex and devastating mental disorder due to its profound impact on individuals, families, and society. Emerging evidence proposes that mitochondria play a central role in schizophrenia. Here, we investigated whether cerebrolysin (CBL) can alleviate anxiety-like beha...

Masserini F, Gendarini C, Baso G, Salvadori E, Pantoni L

Vascular cognitive impairment (VCI) is a common, heterogeneous condition, currently lacking approved treatments.We reviewed therapeutic strategies tested in VCI and meta-analyzed efficacy data for eligible interventions to assess whether previously tested treatments warranted reconsideration.One-...

Kobayashi A, Rutkowska K, Gocyla-Dudar K, Chelstowska B, Pozarowszczyk N, Karlinski M et al.

Intracerebral hemorrhage (ICH) accounts for 15% of strokes with high mortality and limited treatment options. Cerebrolysin, a neuropeptide preparation with multimodal neuroprotective properties, has shown promise in acute ischemic stroke but remains inadequately studied in ICH.CLINCH is an invest...

Lee YS, Seo J, Yim SH

Herpes simplex encephalitis (HSE) is a severe central nervous system (CNS) infection associated with cognitive decline, psychotic symptoms, and epilepsy. Despite aggressive antiviral and corticosteroid treatments, post-HSE complications remain challenging to manage. We report a case of a 33-year-...

Markus HS

Patel PN, Mangal D, Patel K

Cerebrolysin, a neurotrophic compound, has been investigated as a neurorestorative therapy in acute ischemic stroke, although findings are inconsistent due to limitations in study inclusion and outcome reporting. This systematic review and meta-analysis evaluated the efficacy and safety of Cerebr...

Kandasamy G, Arumugam V, Orayj K, Alshahrani AM, Alanazi TS, Hmlan A et al.

Background and Objectives: Acute ischemic stroke is a major cause of disability and mortality. Cerebrolysin, a neuropeptide with neuroprotective and neurotrophic properties, may enhance post-stroke recovery. This study evaluated the impact of adding Cerebrolysin to standard therapy on clinical ou...

Chan TYH, Ma BY, Hung TK, Wong JSY, Lo BWY

Stroke remains a leading cause of global disability, perpetuated by maladaptive neuroinflammation that drives secondary injury and impairs recovery. An early reparative (M2) state rapidly transitions into a dominant destructive (M1) phenotype within days, worsening tissue damage through the relea...

Marchenko SV, Hil IH, Hil UV, Smolskaya NY

We present a clinical case of cancer-associated ischemic stroke in a 70-year-old patient with metastatic sigmoid colon cancer. The patient was admitted to the hospital in the hyperacute stage of ischemic stroke due to thrombosis of the left middle cerebral artery, complicated by severe global aph...

Vosko MR, Sanak D, Do Y, Vatanagul JS, Roushdy T, Bornstein NM et al.

The main objective of the Cerebrolysin REGistry Study in Stroke 2 (C-REGS2) was to systematically record the routine clinical use of Cerebrolysin in patients with moderate ischemic stroke (IS) following the principles of a prospective controlled effectiveness study (CES) to compare its effectiven...

Wesley MJ, Gundala Raja H, Shahid MS, Akbar A, Jeyakumar D, Veluchamy E et al.

This systematic review evaluates the effectiveness and safety of adjunctive neuroprotective therapies administered in combination with reperfusion treatments, either intravenous (IV) thrombolysis, mechanical thrombectomy, or both, in adult patients with acute ischemic stroke (AIS). Following Pref...