Cathelicidin Research

Kosaruk W, Brown JL, Thitaram C

Asian elephants, an iconic flagship species, are increasingly exposed to seasonal pollution and ambient fine particulate matter (PM2.5) due to land burning and regional air pollution across Northern Thailand. Unlike humans and domesticated animals, captive elephants often spend prolonged periods ...

Alkhatib M, Jakobs FM, Hanson JN, Nilson AN, Moritz AE, Li T et al.

Dopamine D4 receptor (D4R) signaling affects decision-making, memory formation, cognition, and attention. Previously developed D4R-selective ligands were metabolically unstable in vivo due to amide bond linker hydrolysis. In this study, analog compounds were synthesized using click chemistry, bio...

Ao X, Peng Y, Chen H, Chmura P, Wei X

The purpose of this study was to compare the differences in physical fitness between different ranked and age youth basketball players. 382 youth basketball players (U18: n = 190; U17: n = 192) participated in the study. Players` sprint, vertical jump, standing long ju...

Zhang F, Lai Z

This study aims to elucidate the ameliorative effects and potential mechanisms of formononetin (FN) on airway inflammation in asthmatic rats. An ovalbumin-induced asthmatic rat model was established and treated with FN. Lung function, histopathology, apoptosis, inflammatory cytokine levels, and l...

Williams MD, Arede J, Gee T, Moran J, Messam S, Howse A et al.

This study examined within-group factors associated with youth basketball players invited to national squad selection camps within Basketball England's talent identification and development system. Data from 253 players (140 males, 113 females) were analysed for relative age, biological maturity,...

Baker KF, Nikiphorou E, Cavalli G, Ganz F, Hegen M, Reinke-Breen L et al.

Peters-Golden M, Fortier SM

The human and economic impact of idiopathic pulmonary fibrosis and other interstitial lung diseases is enormous, and available therapies are of limited utility. A decade after the introduction of the first antifibrotic agents, two new agents are on the horizon. Nerandomilast is an inhibitor of ph...

Tian S, Li Y, Kang J, Yang G, Rao Z, Sun H et al.

To investigate the effect of pterostilbene (PTE), a natural dimethyl ether analog of resveratrol with higher bioavailability, on cognitive recovery after cerebral ischemia reperfusion (IR) injury and its potential mechanisms.Mice were subjected to middle cerebral artery occlusion and assigned to ...

Chauhan C, Kaundal RK

Senegenin is a major bioactive aglycone derived from Polygala tenuifolia Willd. (Polygalaceae), a traditional Chinese medicinal herb ("Yuan Zhi") widely used for the treatment of cognitive impairment and central nervous system disorders. Although senegenin has been reported to exert neuroactive a...

Lower-Hoppe LM, Lo MT, Bates S, Anderson-Butcher D, Ault-Baker KJ

Sport-based positive youth development (SBPYD) programs leverage sport as a context in communities to help youth build competencies and developmental assets, reduce risk factors, and transfer skills learned to other social settings. However, many programs do not fully achieve their objectives due...

Wang Y, Shi Y, Zhang Y, Shi J, Wang Z, Li J et al.

Hydrogen sulfide (H2S), a gaseous neurotransmitter, plays critical roles in neuromodulation and autonomic regulation within the central nervous system (CNS). The supraoptic nucleus (SON), one of a number of hypothalamic regions governing neuroendocrine secretion, also projects to autonomic center...

Xu Y, McConnell BK

Heart failure is a major cause of cardiac mortality in the United States and globally. It occurs when the heart cannot pump enough blood to meet the body's needs, often due to stiffness of the heart muscle or dysfunction in its ability to contract. Cardiac remodeling in heart failure is an adapti...

Wen J, Li Q, Xu S, Lu W, Wu F, Lou J et al.

By virtue of its function as a key metabolic regulator, malignant transformation in the pancreas not only confers high aggressiveness but also disrupts systemic metabolism. However, the causal relationship between metabolic reprogramming and the progression of pancreatic ductal adenocarcinoma (PD...

Li X, Zhang N, Song Y, Zhang T, Lyu Y, Jian H et al.

Ménière disease (MD) is a chronic inner ear disorder of unknown etiology. Although an immune-inflammatory link is suspected, the upstream triggers and cellular mechanisms connecting psychosocial stress to inner ear pathology remain poorly defined. This study aimed to investigate the rol...

Li X, Xiao C, Liu S, Zhang Q, Zhou L, Cai Q et al.

Obesity is characterized by adipocyte hypertrophy and metabolic dysregulation. In this study, a novel polysaccharide (CYP-A) was isolated from Chinese yam. Structural analysis demonstrated that CYP-A is composed of α-L-Araf-(1→, α-D-Glcp-(1→, →5)-α-L-Araf-(1...

Bernadyn T, Kwarcinski F, Chandan N, Gandhi R, Feng Y, Holinstat M et al.

Most adhesion G protein-coupled receptors (AGPCRs) are activated by the intramolecular binding of a tethered agonist, which is exposed by shear force-induced dissociation of the N- and C-terminal fragments of AGPCRs. The decrypted tethered agonist binds to its orthosteric site in the C-terminal f...

Anosri T, Kaewngam S, Prajit R, Suwannakot K, Sritawan N, Aranarochana A et al.

Methotrexate (MTX) is used in treating several malignancies. However, MTX neurotoxicity remains a significant clinical side effect, leading to cell division malformation, and neurogenesis impairment. Chrysin, a flavonoid compound found in natural products, demonstrates various biological characte...

Zhang H, Hao W, Chang H, Bie Y, Sun X

Ischemic stroke is a prevalent neurological disorder, characterized by elevated mortality and significant long-term disability. Oxidative stress damage is an important pathological process that occurs after brain ischemia/reperfusion (I/R), in which the long non-coding RNA death-associated protei...

Ozkuru Sekeroglu E, Yıldız ŞN, Yetkin S, Kafaz GI, Sengez B, Erez O et al.

Epithelial-to-mesenchymal transition (EMT) is a fundamental process in development and disease; however, its study is often complicated by the intrinsic heterogeneity of commonly used epithelial cell models. Here, we show that pre-existing heterogeneity contributes to divergent outcomes following...

Vassiliou PTB, Ainamani HE, Döring S, Gredebäck G, Leku MR, Peltonen K et al.

Growing up in adversity can create enduring deficits in children's cognitive and socio-behavioral skills that undermine later-life productivity, reduce human capital, and increase social costs. Early interventions that target caregiver mental health offer a promising pathway to strengthen the dev...