Carnosine Research

Wilson Alphonse CR, Cyril AC, Parambath AN, Joshy R, Aburamadan H, Radhakrishnan R et al.

Protease Activated Receptor 2 (PAR2/F2RL1) is a G protein coupled receptor, activated by proteolytic cleavage of its N-terminus tethered peptide. Its role in shaping the tumor immune microenvironment across different cancers remains poorly defined. This study presents an integrated immunogenomic ...

Ma L, Ma X, Huang W, Wang J, Yue S, Xu L et al.

Major depressive disorder (MDD) is associated with dysregulation of γ-aminobutyric acid (GABA) and glutamate(Glu) neurotransmission in the prefrontal cortex. Proton magnetic resonance spectroscopy (1H-MRS) enables non-invasive in vivo quantification of GABA and Glx(glutamate + glutamine) le...

Li YY, Yaylayan V, Palin MF, Ngapo TM, Cliche S, Gagnon F et al.

This study assessed the effects of dietary carnosine during the in vitro digestion of a healthy meal model based on the Mediterranean diet, comprising lean pork enriched with two levels of carnosine, whole grain bread, tomato, onion, and olive oil.Lipid and protein oxidation markers were measured...

Farzana S, Islam MM, Nakamura T, Nakamura Y, Munemasa S, Mano J et al.

Our previous results demonstrated that depletion of glutathione (GSH) rather than elevation of levels of reactive oxygen species (ROS) is highly correlated with the decrease in stomatal aperture induced by isothiocyanates (ITCs), although ROS is considered a key second messenger in stomatal closu...

Wei H, Guo S, Ding W, Yang Y, Hu X, Aili A et al.

Exposure to chronic hypobaric hypoxia provokes marked alterations in the gut microbiota and its metabolome, yet the functional significance of histidine-derived metabolites in hypobaric hypoxic pulmonary hypertension (PH) remains underexplored. Here, we employ 16S rDNA, metagenomic, and untargete...

Yamada A, Takahashi M, Ishida T, Khan S, Cline MA, Tachibana T et al.

1. This study investigated the metabolic effects of lipopolysaccharide (LPS, a pathogen-associated molecular pattern derived from gram-negative bacteria) and zymosan (a pathogen-associated molecular pattern derived from fungi) in young chickens (Gallus gallus domesticus).2. Liver RNA-seq analysis...

Takebe H, Sakurai A, Imamura S

Microalgae are increasingly being utilized as sustainable materials for aquaculture feed production. As microalgae-derived compounds, including those with health benefits to humans, can accumulate in the bodies of fish and shellfish, enhancing the production of these compounds will further add va...

Cougo ACTS, de Souza G, Bonjour F, Irigaray BA, Jachmanián I, Brito G et al.

This study investigated the effects of ageing period (5 vs. 90 days) and meat status (raw vs. cooked) in a 2 × 2 factorial design on the concentration of bioactive compounds, intramuscular fat content and fatty acid composition of the longissimus lumborum muscle in beef. Sampl...

Fang X, Wang Y, Yu R, Tang D, Li Z, Qin Q et al.

In the context of increasing freshwater scarcity and the effects of climate change on aquatic environments, developing salt-tolerant fish strains has become a critical strategy for sustainable aquaculture. The limited availability of suitable species for saline-water aquaculture poses a significa...

Carota G, Di Pietro L, Partsinevelos K, Barbati SA, Cardaci V, Graziani A et al.

Endometriosis is a chronic pathological condition characterized by the growth of endometrial-like tissue outside the uterine cavity and is frequently associated with severe pain, persistent inflammation, and fibrosis within the pelvic region and other parts of the body. The exact causes of endome...

Ye X, Zhao Y, Yao Q, Zhang X, Li S, Liu W et al.

Ochratoxin A (OTA) is a core environmental toxin that induces kidney injury by interfering with glomerular filtration, antioxidant defense, and tubular transport functions. Alginate oligosaccharides (AOS), as active substances from marine, carry natural antioxidant, anti-inflammatory and other bi...

Wu J, Huang Q, Li B, Qu Z, Li X, Li F et al.

The sensory quality of pork constitutes a complex phenotype that arises from the interplay between genetic factors and environmental conditions. As a local pig breed in China, Tibetan pigs (TPs) are known for their high-quality meat. However, their slow growth rate and low production efficiency l...

Yuan Y, Huang Y, Li H, Li R, Wang F, Wang Y et al.

After feeding carnivorous mandarin fish (Siniperca chuatsi) with formulated feed, obvious phenotypic differences in body weight and other traits were observed in the fish. Comparative analyses were conducted on the brain tissue transcriptome, intestinal metabolomics, and intestinal microbial dive...

Jung Y, Kim D, Jeong D, Oh S, Park BK, Sujiwo J et al.

This study investigated the effects of shortened rearing periods on meat quality and sensory attributes, aiming to identify an appropriate age range to ensure consumer satisfaction. A total of 320 Hanwoo cattle (n = 80 per age group) were reared from 6 months of age and slaughtered...

Race NS, Uchida K, Burcham PC, Shi R

Acrolein is a highly reactive α,β-unsaturated aldehyde produced endogenously through lipid peroxidation and enzymatic metabolism and exogenously via environmental exposures. Acrolein covalently adducts to DNA and proteins, leading to oxidative stress, mitochondrial dysfunction, and in...

Wozniczka CM, Weaver DF

Alzheimer's disease (AD) remains an unmet medical challenge, as there are no effective therapies that alter the disease's progression. While approaches have targeted molecules like acetylcholine (ACh) and glutamate, these strategies have provided only limited benefits and do not address the compl...

Oni OP, Scott B, Schwartz LC, MacCormack TJ, Hankir M, Rourke JL et al.

N-lactoyl-phenylalanine (Lac-Phe) has emerged as a signaling metabolite connecting cellular metabolism to systemic physiology. Synthesized through carnosine dipeptidase 2-mediated conjugation of lactate and phenylalanine, Lac-Phe increases acutely in response to exercise and feeding, the primary ...

Ishihara S, Shimamoto S, Fujimura S, Kamimura M, Ijiri D

Differences in growth rates among broiler chickens within a single commercial genetic line have important economic implications; however, their molecular basis remains incompletely understood. This study analyzed male Ross 308 broilers classified into early- and late-growth lines based on weight ...

Barbati SA, Carota G, Partsinevelos K, Di Pietro L, Privitera A, Cardaci V et al.

Carnosine (β-alanyl-L-histidine) is an endogenous dipeptide widely distributed in mammalian tissues, especially skeletal and cardiac muscle cells, and, to a lesser extent, in the brain. While early interest in carnosine was given because of its role in muscle cell metabolism and athletic pe...

Kumar A, Suryakumar G, Rathor R

Skeletal muscle is highly susceptible to hypobaric hypoxia linked muscle protein loss due to disturbed proteostasis and redox homeostasis. Carnosine, an endogenous dipeptide possesses antioxidant, anti-inflammatory, anti-glycation and pH buffering properties. The present study investigated the be...