Captopril Research

Almansour AH, Aldhawyan AF

Hypertension is a major public health challenge, particularly in Saudi Arabia, where control rates remain suboptimal. Aim of this study was to describe the epidemiological characteristics and clinical presentation of hypertensive patients visiting the urgent care clinic at a primary healthcare ce...

Laysandro R, Litmantoro Hidayat A, Hanjani Pramudita A

Distal radial and ulnar artery occlusion is a rare condition, especially in the absence of trauma, invasive procedures, vasculitis, or embolic events, and it may mimic neuropathic symptoms, leading to delayed diagnosis.A 32-year-old woman with uncontrolled hypertension, hypercholesterolemia, and ...

Garcia Cano AM, Caja Guayerbas L, Rosillo Coronado M

The diagnosis of primary aldosteronism (PA) requires an Aldosterone-Renin-Ratio (ARR) to demonstrate a low or undetectable renin level and plasma aldosterone concentration that is inappropriately high for salt and volume status. The confirmatory tests are mandatory by the Endocrine Society Guidel...

Peng SL, Wang YH, Cui W, He Q, Hao SF, Wang KJ et al.

Objective: To evaluate the diagnostic utility of confirmatory tests [captopril challenge test (CTT) and seated saline infusion test (SIT)] for primary aldosteronism (PA) using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and establish optimized diagnostic cutoffs. Methods: This prosp...

Gregory KS, Ramasamy V, Sturrock ED, Acharya KR

Angiotensin I-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase involved in blood pressure regulation through proteolysis of angiotensin I (Ang-I) into the potent vasoconstrictor, angiotensin II (Ang-II). Inhibition of ACE is therefore used for the treatment of hypertension,...

Zhu HJ, Zhang YC, Zhang YR, Qin B, Cao X, Wang JN et al.

Microvascular dysfunction is a key contributor to life-threatening diseases, with retinal microvascular diseases being a leading cause of blindness. Aberrant microglia activation is critical in microvasculopathies, but the underlying molecular mechanisms remain unclear. Post-transcriptional modif...

Ahn SY, You YB, Oh HB, Park MA, Yoon SI

DapE is a highly conserved bacterial enzyme that produces L,L-diaminopimelic acid in the meso-diaminopimelic acid and lysine synthesis pathway, which is essential for peptidoglycan formation in the cell wall. DapE has been recognized as a promising antibacterial drug target and can be inhibited b...

Junglas T, Daiber A, Kuntic I, Valar A, Zheng J, Oelze M et al.

Particulate matter (PM) is a significant contributor to air pollution-associated negative health effects, and cardiovascular disease patients are more susceptible to air pollution-mediated damage of the heart and vessels. The present study investigated the protective effects against PM-induced ca...

Taha A, Tariq AA, Mahmood YA, Dias LL, Binu R, Kar SS et al.

The coexistence of multiple complex congenital cardiac anomalies in a single infant - particularly unbalanced Atrioventricular Septal Defect; Double Outlet Right Ventricle; Infracardiac Total Anomalous Pulmonary Venous Connection, situs inversus, and pulmonary hypertension - is exceptionally rare...

Wang M, Zhao J, Tian L, Cao G, Chen Y, Tan J et al.

Cardiac fibrosis is a distinguishing hallmark of ischemic heart diseases with limited therapeutic options due to the incomplete comprehension of cellular heterogeneity. Our previous research demonstrated that Dengzhan Shengmai capsule (DZSMC) could significantly attenuate myocardial fibrosis, yet...

Coffey M, McCrossan B, Moore R, Shields M

ACE inhibitors are commonly prescribed in children. Anecdotally, captopril- induced cough is not thought to occur in children as frequently as in adults.We performed a retrospective cohort study in 100 paediatric cardiology patients taking regular ACE inhibitors (ACE-I). Telephone interviews and ...

Mikheytseva I, Kolomiichuk S, Siroshtanenko T, Storozhuk N, Kuznetsov M, Alobaisi M et al.

 To evaluate the effect of zofenopril on oxidative stress markers and antioxidant enzyme activity in ocular tissues of rabbits with experimentally induced glaucoma. An experimental model of adrenaline-induced glaucoma (AIG) was developed in 2-2.5-year-old rabbits. Zofenopril, an an...

Hamaamin KS, Mahmood NN, Abdulla SK, Rashid BM, Marouf BH, Othman HH et al.

Cyclophosphamide (CYP) is a widely-used chemotherapeutic drug known to induce ovarian damage and infertility in women. The present study evaluated the potential protective roles of zofenopril, a sulfhydryl-containing angiotensin-converting enzyme inhibitor, and thymoquinone (ThQ), alone and in co...

Saman E, Cebova M, Majzunova M, Berenyiova A, Garaiova V, Cacanyiova S et al.

Type 2 diabetes (T2D) associated with obesity is accompanied not only by metabolic but also cardiovascular disorders, including impaired vascular function. In addition to nitric oxide (NO), another gaseous transmitter, hydrogen sulfide (H2S), plays a key role in vascular homeostasis, but its func...

Husain-Syed F, Yuecel G, Daschner C, Jochims J, Yazdani B

Diabetic kidney disease (DKD) remains the leading cause of chronic kidney disease (CKD) and kidney failure worldwide. Over the past three decades, management has evolved from strict glycemic and blood pressure control to targeted therapies that modify disease progression.The DCCT/EDIC (1993) conf...

Ji X, Mu J, Wang Z, Yang X, Chen C

To report a rare case of primary hyperaldosteronism initially presenting with bilateral branch retinal vein occlusion (BRVO).Having a 17-year history of poorly controlled hypertension, a 62-year-old male patient suffered from recurrent macular edema secondary to bilateral BRVO.Laboratory tests re...

Yang W, Zou X, Zhang T, Liu Q, Liu Z, Li F et al.

This study aimed to identify novel angiotensin-converting enzyme (ACE)-inhibitory peptides from royal jelly proteins (RJPs) by integrating in silico digestion, virtual screening, and in vitro evaluation. Three major royal jelly proteins (MRJP1-3) were subjected to in silico digestion using 16 enz...

Tan YF, Fu YH, Zhang MZ

This study aimed to investigate the effects of Tongguan Capsules(TG) on isoproterenol(ISO)-induced heart failure(HF) in rats, and to comprehensively predict the potential molecular mechanisms underlying TG's effects in improving HF based on transcriptomic analysis. Additionally, the study explore...

Wang Q, Dong H, Li HW, Zou YB, Jiang XJ

This study investigated whether patients receiving renin-angiotensin system inhibitors (RASIs) can undergo reliable screening for primary aldosteronism (PA) without discontinuation of therapy. Consecutive patients with hypertension who underwent PA screening at our hospital between 2016 and 2024 ...