Capromorelin Research

Wofford JA, Milliken MacKinnon A, Heinen E

ObjectivesThe aim of the study was to evaluate the efficacy and safety of capromorelin to manage weight loss in cats with unintended weight loss, as occurs in chronic kidney disease (CKD), in a randomized, masked, placebo-controlled, multicenter clinical field study.MethodsA total of 176 client-o...

Mealey KL, Burke NS

The drug transporter P-glycoprotein (P-gp) influences drug disposition by playing key roles in limiting brain penetration and enhancing biliary excretion of substrate drugs. Guidance documents from U.S. and European regulatory agencies recommend that manufacturers determine the P-gp substrate sta...

Susi IR, Viviano K, Whitehouse WH

Over the past 10 years, feline medicine has significantly advanced through the addition of new pharmaceuticals and alternative formulations available for cats, as well as improvements in the knowledge about existing agents. Through continued drug development, the therapeutic options for cats are ...

Titel C, Doss G, Mans C

These studies aimed to evaluate the appetite-stimulating effects of capromorelin, cyproheptadine, and mirtazapine in budgerigars (Melopsittacus undulatus). The effects of a single oral dose of capromorelin (10 and 40 mg/kg), cyproheptadine (0.5 and 2.5 mg/kg), and mirtazapine (1 and 5 mg/kg) on f...

Di Girolamo N, Maranville RE, Pathak D, Womble W, Hanzlicek A, Sypniewski L et al.

To determine the effects of drugs with potential prokinetic effect through different mechanisms of action (metoclopramide, cisapride, pyridostigmine, and capromorelin) on food consumption, fecal production, water intake, and urine output in rabbits.In a randomized, blinded, complete crossover con...

Xu H, Liu M, Jia X, Zhao S, Xia Y, Lu B et al.

Recombinant human growth hormone (rhGH) is a well-established treatment for children with growth deficiencies worldwide. However, its requirement for subcutaneous administration limits convenience compared to that of oral therapies. Starting from capromorelin, we designed, synthesized, and charac...

Trumpp K, Burns L, Jacobson C, Divers SJ

Weight loss and decreased appetite are commonly encountered sequela of disease and stress in avian patients. However, there is currently minimal information in the veterinary literature regarding appetite stimulation in birds. Capromorelin is a potent agonist of the growth hormone secretagogue re...

Punger EM, Norris SLW, Stevens SC, Santos KH, Christy AC

Significant weight loss in mice (Mus musculus) is a welfare concern and can alter physiology and behavior in ways that may confound research aims. In this study, factorial design was used to investigate the effect of enterally administered capromorelin on changes in mouse body weight overall and ...

Campellone GA, Easley KA, Jenkins JB, Jean SM

Nonhuman primates used in biomedical research may experience clinically significant weight loss for a variety of reasons. Episodes of anorexia (complete loss of appetite) or hyporexia (decreased appetite) can result in significant weight loss, potentially altering animal welfare and scientific st...

Ringuet MT, Koo A, Furness SGB, McDougall SJ, Furness JB

Agonists of dopamine D2 receptors (D2R), 5-hydroxytryptamine (5-HT, serotonin) receptors (5-HTR) and ghrelin receptors (GHSR) activate neurons in the lumbosacral defecation centre, and act as 'colokinetics', leading to increased propulsive colonic motility, in vivo. In the present study, we inves...

Sobolevsky T, Walpurgis K, Goergens C, Fedoruk M, Lewis L, Ahrens B et al.

Capromorelin is a growth hormone secretagogue. Despite promising results to alleviate muscle-wasting in the elderly, it has not advanced further in human development. Subsequent studies demonstrated capromorelin's ability to increase food intake in animals, leading to approval in the United State...

Rathore M, Das N, Ghosh N, Guha R

Growth hormone and insulin like growth factor-1 plays an important role in the regulation of body composition and metabolism. Growth Hormone is released from the pituitary through a specific G-protein coupled receptor (GPCR) called growth hormone secretagogue receptor 1a expressed in the hypothal...

Draper JM, Savson DJ, Lavin ES, Feldman ER, Singh B, Martin-Flores M et al.

Inappetence is a welfare concern in rabbits (Oryctolagus cuniculus), as it can lead to potentially fatal gastrointestinal stasis. In other species, inappetence is commonly treated with appetite stimulants; however, few published studies have evaluated the efficacy of appetite stimulants in rabbit...

Pascutti KM, O'Kell AL, Hill RC, Castro RA, Salute ME, Gilor C et al.

Capromorelin is a ghrelin-receptor agonist widely used as an appetite stimulant in dogs. Capromorelin disrupts glucose homeostasis in cats but information regarding its effects on canine glucose homeostasis is lacking. The study objective was to evaluate the effect of capromorelin on glucose home...

Ceron-Romero N, Taofeek N, Thomas A, Vroonland E, Sanmartin K, Verghese M et al.

Ghrelin is a hormone that induces orexigenic effects in mammals. However, in avian species, there is scant and conflictive results on the effect of ghrelin on feed intake (FI). Therefore, we evaluated the effect of a ghrelin receptor agonist (capromorelin) on FI, ADG, water intake (WI), animal be...

Lange T, Thomas A, Görgens C, Bidlingmaier M, Schilbach K, Fichant E et al.

Analytical methods to determine the potential misuse of the ghrelin mimetics capromorelin (CP-424,391), macimorelin (macrilen, EP-01572) and tabimorelin (NN703) in sports were developed. Therefore, different extraction strategies, i.e. solid-phase extraction, protein precipitation, as well as a "...

Pazan F, Petrovic M, Cherubini A, Onder G, Cruz-Jentoft AJ, Denkinger M et al.

Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty.A literature search was performed in Medline to detect prospective randomized contr...

Pires J, Greathouse RL, Quach N, Huising MO, Crakes KR, Miller M et al.

Somatostatin secretion from islet delta cells is important in maintaining low glycemic variability (GV) by providing negative feedback to beta cells and inhibiting insulin secretion. Capromorelin is a ghrelin-receptor agonist that activates the growth hormone secretagogue receptor on delta cells....

Chai XY, Diwakarla S, Pustovit RV, McQuade RM, Di Natale M, Ermine CM et al.

Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). The toxin 6-hydroxydopamine (6OHDA) produces the symptoms of PD, surprisingly including constipation, after it is injected into the medial forebrain bundle (MFB). However, the mec...

Johannes CM, Musser ML

Appetite influences perceived quality of life for a dog or cat with cancer. Inappetence often is multifactorial, complicating treatment. Cancer-related anorexia/cachexia syndrome is a metabolic, paraneoplastic syndrome characterized by decreased food intake, involuntary weight loss, and loss of f...