Calcitonin Research

Lipton RB, Dodick DW, Davis L, Nahas SJ, Goadsby PJ

To assess the role of small-molecule calcitonin gene-related peptide receptor antagonists (gepants) in the acute treatment of migraine, particularly in relation to triptan treatments.Triptans have established efficacy and are widely prescribed for the acute treatment of migraine. However, triptan...

Wang J, Wang F, Liu J, Xiao Y, Li Z, Liu X et al.

Chemotactic migration of peritendinous nerves is essential for tendon regeneration, yet the underlying neuroelectrical mechanisms remain unclear. Here, we identify an electrically responsive yes-associated protein 1 (YAP1)/phosphorylated signal transducer and activator of transcription 3 (pSTAT3)...

Xu S, Song W, Wang Y, Zhao Y

The objective of this study was to investigate the potential association between the use of calcitonin gene-related peptide (CGRP) antagonists and the reporting of cardiac adverse events (cAEs) by analyzing data from the US Food and Drug Administration Adverse Event Reporting System (FAERS). CGRP...

Song Y, Chen J, Yu J

Multiple endocrine neoplasia (MEN) syndromes are a group of rare autosomal dominant hereditary disorders that are classified into 5 distinct types. MEN2A, the most common type of MEN2, is associated with mutations and variants of RET, which are continually being updated. However, studies regardin...

Bindhani BK, Devi NK, Saraswathy KN

Sickle cell trait (SCT) has long been considered a benign carrier condition; however, emerging evidence suggests that individuals with SCT may experience adverse health outcomes, both physical and mental. These findings challenge the conventional notion of SCT as clinically insignificant. Therefo...

Kucera KL, Agans RP, Robbins PA, Yang Y, Schmid L, McDonald MA et al.

This paper describes methods for a national study evaluating the implementation of the National Collegiate Athletic Association's (NCAA) policy on sickle cell trait (SCT) screening of athletes and describes attitudes toward the screening.In Fall 2020, 343 Division I schools, 302 Division II schoo...

Bou Malhab FM, Jabbour SA, Defronzo R, Nemr R

The pancreas is innervated by a complex network including vagal, sympathetic, and spinal sensory pathways but recent studies suggest that the trigeminal system, known for its role in sensory perception, may also contribute to pancreatic innervation.This review explores the hypothesis that the tri...

Alvarez M, Luna M, Suarez E, Rincon O, Guzman I, Mancera P et al.

Collision tumors of the thyroid are rare entities, defined by the coexistence of two histologically distinct tumors within the same organ, separated by intervening normal tissue. Graves' disease (GD) is a well-known risk factor for papillary thyroid cancer but has not been associated with thyroid...

Zhang X, Bao H, Hu J, Ren W, He Z, Yu-Taeger L et al.

Chronic neuroinflammation and dysfunction of the neuro-glial-vascular unit (NGVU) are central mechanisms driving the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Neuropeptides, as key regulatory signaling molecules in the central nervous system (CNS), bin...

Fitzek MP, Kleist P, Handtmann C, Overeem LH, Hoehne CL, Lange KS et al.

Oxytocin has been implicated in migraine pathophysiology through its roles in pain modulation and vascular regulation. Its receptors are present in migraine-related brain regions and cerebral vessels and interact with key migraine mediators such as calcitonin gene-related peptide (CGRP). Declinin...

Chu H, Pan J, Huang C

This study aimed to observe the efficacy and safety of rimegepant, a small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist, for the acute treatment of vestibular migraine (VM).Patients meeting the diagnostic criteria for VM or probable VM received rimegepant 75 mg for acu...

Fawzy AM, Patel PA

Compassionate stem cell therapy (CST) is a potential treatment option for patients with end-stage heart failure who have exhausted all standard options. However, CST remains experimental. Its merits in treating heart failure are still being investigated with evidence so far suggesting limited or ...

Sun X, Yang H, Leng Z, Zhang W, Jiang Z, Liu H et al.

Recurrent miscarriage (RM) remains a significant clinical challenge due to its elusive pathogenesis. This study aimed to investigate the role of chemokine ligand 12 (CXCL12) at the maternal-fetal interface and its specific mechanism in RM, to provide an experimental basis for potential diagnostic...

Giannotti CF, de Oliveira NSP, Garcia JG, Petrilli MT, Viola DCM, Garcia RJ et al.

The Aneurysmal Bone Cyst (ABC) is a benign yet aggressive bone tumor. This study aimed to evaluate sex, age, tumor location, tumor size, type of treatment (surgical, infiltration, embolization), and recurrence.Descriptive and quantitative statistical analyses were applied. The prevalence ratio an...

Noroozzadeh M, Changaei M, Farhadi-Azar M, Mousavi M, Ramezani Tehrani F

Polycystic ovary syndrome (PCOS) has been associated with conflicting effects on bone mass, underscoring the need for deeper investigation into its impact on skeletal health. This study aimed to assess the expression of osteoporosis-related genes in femoral bone, alongside hormonal profile (bone-...

Su Y, Wang H, Liu W, Chen K, Min Y, Zhu J et al.

The skeletal interoception system that orchestrates bone homeostasis and regeneration through a coordinated "afferent-integration-efferent" reflex arc has been overlooked in bone tissue engineering. The dorsal root ganglion (DRG) neurons constitute the hubs of this system. Moreover, beyond their ...

Abdelwahed OM, Aboulhoda BE, Gouda SAA, Shoukry T, Rashed L, Alkaffas M et al.

The spleen plays a crucial role during inflammation through its resident macrophages, which may be influenced by modulations in neurochemical levels inside the spleen. Transient receptor potential vanilloid 1 (TRPV1) was reported to modulate the immune responses; however, its role in the spleen r...

McIlvried LA, Matos AAM, Krane RS, Eskew KT, LeGrande T, Atherton MA et al.

Peripheral sensory nerves are thought to play a role in solid tumor growth, particularly in oral squamous cell carcinoma (OSCC); however, the link between pain and immunosuppression remains unresolved. Here, we find an inverse relationship between OSCC-associated pain by way of calcitonin gene-re...

Prete A, Matrone A, Romei C, Gambale C, Bottici V, Casalini R et al.

In multiple endocrine neoplasia type 2 (MEN2), clinical management of gene carriers (GCs) is still debated, especially in MEN2A. We aimed to evaluate the predictive value of preoperative CTN for medullary thyroid cancer (MTC) diagnosis and excellent response (ER) in MEN2A GCs.Retrospective evalua...

Budzich-Napiwodzka M, Cholewik M, Góralska M, Nadolska I, Koperski Ł, Ambroziak U et al.