BPC-157 Research

Moksi L, Sissala N, Ojala R, Lehenkari P, Valkealahti M

Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger population, the consequent arthroplasty of the hip is a radical procedu...

Velleuer E, Carlberg C

Fanconi anaemia (FA) is a DNA-repair disorder that compresses multiple hallmarks of ageing into childhood and early adulthood. Persistent genomic instability in FA precipitates oxidative stress, inflammatory remodelling, and metabolic reprogramming, which together erode epigenetic integrity and i...

Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O et al.

Background: No Fourier transform infrared (FTIR) spectroscopy studies have directly evaluated adrenalectomy vessels, the technique's established ability to probe collagen/elastin-associated spectral features and lipid peroxidation-related signatures, and protein structural damage. Stable gastric ...

Madzarac G, Becejac T, Penovic T, Drazenovic D, Kralj L, Popović Dolic M et al.

Background/Objectives: This 7-day rat tracheocutaneous fistula study considered the not-studied issues of tracheocutaneous fistula course, wound healing, and fistula in the NO-system relations. Therefore, we focused on fistulas' severe course, tracheocutaneous fistula → air leak → c...

Rahman OF, Lee SJ, Seeds WA

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-β, and AMPK, peptides exert influen...

Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF et al.

Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients. Given the increase in the development of...

Masnec S, Kokot A, Kralj T, Zlatar M, Loncaric K, Sablic M et al.

To better address the challenge of corneal ulcer healing, with already available standard agents, and those recently introduced, such as stable gastric pentadecapeptide BPC 157, we introduced a novel conceptual framework-the "triad" of corneal ulcer healing↔corneal neovascularization&#x219...

Dobkowska-Szefer D, Staśkiewicz-Bartecka W, Kiciak A, Kardas M

The prevalence of disordered eating behaviors and body image disturbances among athletes in weight-category sports remains insufficiently explored, especially in combat disciplines such as contact karate. The present study aimed to assess the risk of eating disorders and body image perception amo...

Rintala JM, Koskela M, Peroja P, Huhta H, Saarnio J, Pohjanen VM et al.

The combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is widely used to treat pseudomyxoma peritonei (PMP), peritoneally metastasized colorectal or appendiceal cancer (pmCRC or pmAppCa) and peritoneal mesothelioma, although the specific efficacy of H...

Józwiak M, Bauer M, Kamysz W, Kleczkowska P

We wish to thank the Authors of the comment for their interest in our manuscript [...].

Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A et al.

The healing issue is a central, not completely understood, problem in pharmacology, approached by many concepts. One of the most well-known is Robert's and Szabo's concept of cytoprotection, which holds innate cell (epithelial (Robert), endothelial (Szabo)) integrity, protection/maintenance/reest...

Yeh ZY, Mushyakhwo K, Ni NT, Lo PH, Lin CF, Nai YS et al.

The Purpureocillium lilacinum NCHU-NPUST-175 (Pl-NCHU-NPUST-175) strain has been previously reported as an entomopathogenic fungus (EPF) with potential for controlling Forcipomyia taiwana (little black mosquito). In this study, genome sequencing of Pl-NCHU-NPUST-175 was performed via long-read se...

Majcherek E, Jaskulska J, Drejza M, Plagens-Rotman K, Kapczuk K, Kędzia W et al.

Background/Objectives: Pediatric and adolescent gynaecology addresses the distinct developmental needs of the reproductive systems of young patients. Diagnosing and treating gynaecological issues in this age group are challenging due to overlapping symptoms and the developmental stage. This study...

McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM

This scoping review aims to evaluate the molecular mechanisms, therapeutic potential, and safety concerns of Body Protective Compound-157 (BPC-157) in the context of musculoskeletal healing. Given the compound’s increasing availability, popularity, and its regulatory controversies, we soug...

Whitehouse M

This article discusses the lengthy review by Pedrag Sikiric and twenty one (21) co-authors in Inflammopharmacology (2024) 32:3119-3161.© 2025. The Author(s).

Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE et al.

Background: Body protection compound-157 (BPC-157) is a naturally occurring gastric peptide that promotes mucosal integrity and homeostasis. Preclinical studies show its potential for promoting healing in musculoskeletal injuries such as fractures, tendon ruptures, ligament tears, and muscle inju...

Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A et al.

Although approached through many concepts, the pleiotropic healing issue, specifically, maintaining/reestablishing tissue integrity, remains a central challenge in pharmacology, particularly when the process is misdirected or not properly controlled. Robert and Szabo's concept of cytoprotection h...

Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A et al.

In this study, pharmacotherapies of abdominal compartment syndrome (ACS) and intra-abdominal hypertension (IAH) in animal studies were reviewed from the perspective of ACS/IAH as failed cytoprotection issues, as non-specific injuries, and from the point of view of the cytoprotection concept as re...

Luo Q, Zhu Z, Wan L

To investigate and validate the protective role of plumbagin (PL) in renal ischemia-reperfusion injury (IRI) by mediating the Nrf2/HO-1 pathway and reducing renal function damage, thereby providing a theoretical basis for the application of PL in the prevention of renal IRI.Twenty-four healthy ad...

M Lopes AL, Kolling GB, E Silva LO, Alves RLOR, de Assumpção FM, Leite SKM et al.

The aim of this study was to evaluate the effects of two strategies for induction of ovulation prior to the first timed-artificial insemination (TAI) protocol on reproductive outcomes of yearling Nelore (Bos indicus) heifers. On Day -24, a total of 2000 heifers (12.3 ± 0.03 mo...