B-type Natriuretic Peptide (BNP) Research

Papa A, Balzan S, Lubrano V, Sabatino L

Atherosclerosis and diabetes are largely recognized as inflammatory disorders underlying cardiovascular disease. C-reactive protein, interleukin-6 and fibrinogen constitute the most established inflammatory biomarkers in clinical practice for the characterization of individuals affected by athero...

Xu Y, Shi Y

The pathophysiological mechanism of neurogenic pulmonary edema (NPE) is still unclear, and the condition is severe with a high mortality rate. Identifying the risk factors for NPE is of great significance. Therefore, this study aims to explore the risk factors of hypertensive intracerebral hemorr...

Somarathinam K, Gunalan S, Sundaramoorthy A, Dhanusu S, David SJ, Anthony A et al.

Hypertension and associated cardiac hypertrophy remain major global health challenges, demanding safer and more effective therapeutic agents. This study investigates boerhadiffusene, a terpenoid isolated from Boerhavia diffusa L., as a potential antihypertensive and cardioprotective lead molecule...

Shoshina AA, Nasonova SN, Zhirov IV, Tereshchenko SN

To evaluate the efficacy and safety of the use of sodium-glucose cotransporter type 2 (SGLT-2) inhibitors in patients with chronic heart failure (CHF) due to amyloid cardiomyopathy (ACM).50 patients with CHF due to different types of ACM were included and randomized in two groups at a ratio of 1:...

Alowami M, Ch'ng BX, Babasola RO, Tan CH, Koh MH, Harvard A et al.

Selexipag, a selective prostacyclin receptor agonist, has been evaluated in randomized controlled trials (RCTs) for the treatment of pulmonary hypertension (PH), but results remain inconsistent. We performed an updated meta-analysis to assess its efficacy and safety. PubMed, Embase, and Cochrane ...

van Maarschalkerwaart WA, Wierda E, de Boer D, Jonkman NH, Boersma E, Brugts JJ et al.

Outpatient intravenous (IV) diuretic treatment is an effective and safe strategy for worsening heart failure (WHF). Still, hospitalization cannot be avoided in a substantial portion of patients and potential predictors of HF hospitalization (HFH) are eagerly awaited.We aimed to identify predictor...

Troger F, Pamminger M, Tiller C, Holzknecht M, Lechner I, Kaser A et al.

T2-mapping of the blood-pool in cardiac magnetic resonance imaging (CMR) provides important information on blood-oxygenation, and differences between right and left ventricular (RV/LV) T2-relaxation times are linked to exercise capacity in heart failure. However, there are no data available on RV...

Koyama K, Hashimoto N, Arimoto T, Kutsuzawa D, Watanabe K, Kobayashi Y et al.

Combined assessment of the left and right atrial overload has been associated with atrial fibrillation recurrence after catheter ablation.This study aimed to investigate whether liver fibrosis scores are associated with right atrial remodeling and evaluate the prognostic value of combining these ...

Wu F, Chen X, Chen K, Wei J, Gong C, Wu W et al.

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vasoconstriction and vascular remodeling, leading to increased pulmonary vascular resistance, pathological right ventricular (RV) remodeling, and ultimately right heart failure and death. RV function and right ventricle-pulmonary...

Xie S, Chang C, Tran TM, Zhou Z, Yu C, Chen Y et al.

Diabetic cardiomyopathy (DCM) is a serious complication of end-stage diabetes that manifests as cardiac hypertrophy and heart failure. The present study performed a bioinformatics analysis to predict possible targets for aerobic exercise to improve DCM, and animal experiments were conducted to de...

Zeng M, Li Q, Li L, Xiang CF, Wang YJ

Sepsis, a common and severe infectious disease, remains one of the leading causes of mortality among patients, with myocardial injury representing a major contributor to adverse outcomes. Melatonin, an endogenous hormone, is known to regulate oxidative stress and inflammatory responses; however, ...

Xue S, Ye Q, Lazarević A, Hamzaraj K, Binder P, Nitsche C et al.

Aortic stenosis (AS) induces myocardial remodeling and fibroblast activation, yet modifiable biomarkers capable of capturing active fibrogenesis and predicting post-transcatheter aortic valve implantation (TAVI) recovery are currently scarce. Fibroblast activation protein (FAP)-targeted PET serve...

Sato R, Yamagishi K, Jinnouchi H, Muraki I, Yasuoka M, Kakihana H et al.

Evidence regarding the association between heart failure and sarcopenia in middle-aged and older community-dwelling adults is scarce. This study aimed to examine the association between NT-proBNP levels and sarcopenia among community-dwelling adults aged 40-74 years.This cross-sectional st...

Weng L, Li H, Lv Y, Luo J, Wen Z, Shi J et al.

Sepsis remains a major cause of mortality in ICU patients, requiring accurate prognostic tools for optimal management. This study aimed to develop and validate an interpretable machine learning-based nomogram for predicting in-hospital mortality in sepsis patients to guide clinical decision-makin...

Liu Z, Zhou Z, Yuan W, Li J, Tian J, Li M et al.

Heart failure (HF) represents the clinical end stage of most cardiovascular diseases and remains a major cause of mortality, morbidity, and poor quality of life worldwide. In the present study, we use a mouse model induced by abdominal aortic constriction (AAC) that mimics HF and evaluate the pot...

Beyazal M, Keceli M, Dogan O, Ece I

Background: Cardiac magnetic resonance [CMR] is a non-invasive tool to assess ventricular function in pediatric pulmonary arterial hypertension [PAH]. However, CMR parameters in children remain underexplored. Methods: Thirty-six children with PAH were prospectively evaluated using CMR. Right and ...

Luo Y, Lai J, Li C, Wang G

Cardiac transplantation remains an important therapy for end-stage heart failure, although allograft rejection continues to pose significant clinical challenges. This review evaluates both established and emerging blood-based biomarkers for noninvasive monitoring of rejection in heart transplant ...

Wang F, Jin S, Lyu S, Zhao X, Lyu X, He Q et al.

Patients undergoing pancreaticoduodenectomy for distal cholangiocarcinoma (dCCA) face a substantial risk of major postoperative cardiac complications (MPCC), which significantly impact mortality and recovery. Existing risk assessment tools lack objective cardiac functional parameters. This study ...

Wei HQ, Li H, Liao H, Liang Y, Zhang Q, Deng H et al.

Left bundle branch area pacing (LBBAP) is considered to be an alternative modality to deliver cardiac resynchronization therapy (CRT). However, left bundle branch pacing and left ventricular septal pacing (LVSP) are characterized as left bundle branch area pacing. The long-term effect of only LVS...

Kawazoe N, Kubota Y, Nishino T, Ogane M, Iwade Y, Hayashi D et al.

This study aimed to examine the predictive factors and timing of delirium onset in hospitalized patients with heart failure, focusing on the impact of total anticholinergic load and other contributing variables.The single-site retrospective cohort study included 694 patients hospitalized for hear...