Beta-Endorphin Research

Li X, Wu T, Li W, Xing Q, Bao W

The aim of this study was to evaluate the preventive effect of transcutaneous acupoint electrical stimulation (TEAS) on emergence agitation after general anesthesia in pediatric patients undergoing tonsillectomy.This prospective, randomized, controlled trial was conducted between January 2025 to ...

Wang H, Chen W, Chen G, Zhu K, Zhang K, Li D et al.

BACKGROUND Postoperative pain following total knee arthroplasty (TKA) is a substantial clinical challenge, often complicating recovery. Electroacupuncture (EA) has garnered interest as a potential intervention, yet its definitive efficacy and safety profile in the context of TKA remain subjects o...

In the article "Sex Differences in Brain and Plasma β-Endorphin Content following Testosterone, Dihydrotestosterone and Estradiol Administration to Gonadectomized Rats" [Neuroendocrinology. 2009;89(4):411-423; https://doi.org/10.1159/000209506] by Pluchino et al., the following should be no...

Feng K, Zhao Y, Liu L, Kang S, Yu M, Sy SKB et al.

Nicotine addiction is a major public health challenge, with existing pharmacological interventions often limited by suboptimal efficacy, adverse effects and withdrawal symptoms.This study explores the effects of combining levo-tetrahydropalmatine (l-THP), a dopamine receptor antagonist, with low-...

Wu S, Fu J, Xie C, Chen X

This study investigated the association between the ABCB1 (MDR1) C3435T (rs1045642) gene polymorphism and postoperative analgesia in patients undergoing hip replacement surgery. A total of 100 patients who underwent hip replacement in our hospital between January 2023 and January 2024 received po...

Wang G, Kong X, Li X, Chen C, Zhang K, Zhou Y et al.

Clinical management of trigeminal neuralgia (TN) is hindered by poor neural bioavailability and systemic toxicity of oral drugs. While the nasal route offers a direct pathway to target the trigeminal nerve, rapid mucociliary clearance and competition from systemic absorption limit its effectivene...

Zhu S, Wu C, Pu B, Nie J, Song H, Su X et al.

To assess the clinical efficacy of acupressure application in treating postherpetic neuralgia (PHN) of the qi (vital energy) stagnation and blood stasis type, as well as its impact on blood inflammatory factors, T-cell subpopulations, and neurotransmitter levels.A total of 134 patients diagnosed ...

Abdullaeva C, Coughlin D, Alyamni N, Zestos AG

Endorphins are three proteins that belong to a family of neuropeptides that regulate pain perception, mood, and immune function by targeting opioid receptors. The biological role of ꞵ-endorphin is well studied, but α- and γ-endorphins are less understood. By creating more fast ...

Huang F, Liu Y, Qiu S

To retrospectively explore how sevoflurane + sufentanil/remifentanil versus propofol + sufentanil/remifentanil impacts clinical outcomes in laparoscopic herniorrhaphy-treated adults.We enrolled 102 adult patients grouped into propofol (n=50) and sevoflurane (n=52) groups. Inter-group comparisons ...

Delanerolle G, Phiri P, Elneil S

Boxing, traditionally a competitive sport, is increasingly recognised as a therapeutic exercise modality for women transitioning through perimenopause and menopause a life stage characterised by hormonal changes that can accelerate muscle loss, bone demineralisation, balance impairment, cardiovas...

Pham A, Osmundson SS, Pedowitz A, Wickersham N, Sorabella LL, Bruehl S et al.

Prior laboratory work indicates that lower endogenous opioid function is associated with greater analgesic and subjective responses to opioid analgesics. We evaluated whether preoperative cerebrospinal fluid (CSF) concentrations of the analgesic endogenous opioid β-Endorphin (BE) were assoc...

Bruun KD, Moerkeberg MCR, Pedersen JR, Broholm D, Blichfeldt-Eckhardt MR, Abildgren L et al.

The opioid system is involved in the regulation of pain as well as stress homeostasis. Stress-induced opioid dysregulation has been proposed as a mechanism for pain development in patients with fibromyalgia (FM) and chronic low back pain (cLBP). However, the evidence to support this hypothesis is...

Hébert-Losier K, Knighton H, Finlayson S, Peterson B

We examined the perceptions and experiences of male recreational runners when using minimalist racing flats (FLAT, Saucony Endorphin Racer 2) and advanced footwear technology (AFT, Nike Vaporfly 4%) shoes, compared with their habitual shoes (OWN). Eighteen runners completed three 1.5 km outdoor t...

Ostapiuk-Karolczuk J, Dziewiecka H, Kasperska A, Cichoń-Woźniak J, Reysner M, Gruszka W et al.

Anxiety is a key psychological factor in competitive sport that interacts with physiological stress responses. By modulating neuroendocrine and neurotransmitter activity, it may influence how athletes adapt to maximal effort and recover afterward. The study addressed the gap in understanding how ...

Perdana LP, Fabillar J, Arini DS, Raman S, Raju R, Ikutame D et al.

Interleukin-10 (IL-10) is a cytokine that can exert an analgesic effect on trigeminal neuropathic pain (TNP). However, its precise mechanism remains unclear. In this study, we investigated the antinociceptive effects of recombinant IL-10 (rIL-10) in a rat model of infraorbital nerve constriction....

Gangadharan S, Nisar MK

Physical activity (PA) is vital for managing menopausal symptoms and reducing noncommunicable diseases in middle-aged women. Despite the known benefits, many women do not meet the recommended activity levels and view household tasks as sufficient owing to factors such as time constraints, lack of...

Santos MF, Randa J, Tai D, Vistoli G, Schahaf NA, Vittorio S et al.

Physical exercise affects multiple physiological processes, including those regulated by hormones, such as energy balance, stress responses, and pain perception. The prohormone precursor proopiomelanocortin (POMC) gives rise to β-endorphin, adrenocorticotropic hormone, β-lipotropin, a...

Zhong C, Zhu F, Liang Q

This study aims to evaluate the immediate analgesic effect and safety of cervical localized rotation manipulation (CLRM) combined with cervical Huatuo-Jiaji electroacupuncture (CHJE) on cervicogenic headache (CEH) in a retrospective controlled study. A total of 300 patients with CEH who visited t...

Zhao D, Mi L, Chen Y, Sun X, Ma Z, Hao L et al.

This study aimed to investigate the relationship between serum inflammatory markers (TNF-α, IL-6, CRP) and cerebrospinal fluid (CSF) cytokine levels (AVP, OT, β-EP) with the severity of postoperative neurological injury and prognosis in patients with glioma.In this retrospective study...

Yamamoto H, Sawaguchi Y, Koida A, Yamada T

Proopiomelanocortin (POMC), a precursor with multiple bioactive peptides, is expressed by keratinocytes and regulates various pathophysiological responses, including pruritus associated with atopic dermatitis (AD). In the skin, POMC is extracellularly processed into peptides like α-melanocy...