BDNF Mimetic Peptides Research

Davies LJ, Whitefield C, Kim H, Nitsche C, Jackson CJ, Frkic RL et al.

Heparanase is the sole enzyme responsible for breaking down heparan sulfate within the extracellular matrix, and its overexpression is linked to human diseases. Despite heparanase being a promising drug target, most efforts have focused on substrate mimetics, which have failed clinical trials, hi...

Evans S, Singh R, Ahring K, Ashmore C, Daly A, Ford S et al.

Casein glycomacropeptide (cGMP) has been modified to enable its suitability as a low phenylalanine (Phe) protein substitute (PS) in phenylketonuria (PKU). No data is available about its global usage.A 60-item multiple choice and short answer/extended response questionnaire examining the use of mo...

Ardila N, Guzmán F, Suárez-Barrera MO, Cruz J

Parasporin PS2Aa1, recently designated as Mpp46Aa1, is recognized for its selective anticancer activity against various human cell lines. In this study, specific regions of the native protein were fragmented, and targeted amino acid substitutions were introduced to improve cytotoxic selectivity a...

Wang Y, Meng X, Zhang X, Chen R, Zhang M, Yang D et al.

Low-intensity pulsed ultrasound (LIPUS) shows promising anti-inflammatory and neuroprotective effects for different types of neurological disorders. This study aims to investigate the therapeutic effects of LIPUS on LPS-induced depression-like behavior and neuroinflammation and to elucidate the u...

Idoudi F, Wang R, Tian L, Yang Z, Chik KK, Chen P et al.

Wild dromedary camels in the Arabian Peninsula and Africa have harbored antibodies against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) for decades, predating zoonotic spillover to humans. However, the potency, specificity, and structural characteristics of these antibodies remain poor...

Chen Y, Yang W, Li G, Hu Y, Zhang J

Aiming to meet the critical need for user-friendly and sensitive clinical analysis platforms, an all-in-capillary SERS analytical system integrated with a visible-light-enhanced nanozyme for highly sensitive and convenient biomarker detection was developed. The system employs a hierarchical tande...

Baumeister J, Erhardt M, Wilhelm JG, Lam K, Ebert S, Rosenau F et al.

Monoclonal antibodies (mAbs) are prone to post-translational modifications during manufacturing and storage, which can affect product quality. Modifications within the complementarity-determining regions (CDRs) impairing antigen interaction are considered as critical quality attributes. A modular...

Jiang Y, Chu B, Ma W, Liu M, Zhang S, Xi D et al.

Accurate disease diagnosis requires analyzing multiple biomarkers in a single sample to improve diagnostic precision and guide treatment. However, the simultaneous detection of three or more proteases in a sample, especially with a single probe, remains a major challenge. Herein, we developed a t...

Chen X, Ma L, Bai Z, Wu J

Progastrin-releasing peptide is a crucial serum biomarker for the diagnosis, differential diagnosis, therapeutic monitoring, and prognostic evaluation of small cell lung cancer. In this study, a double-antibody sandwich immunoassay for the biomarker was developed. Key factors in the method develo...

Huang Z, Jin P, Pan H, Wei M, Liang Q, Gan M et al.

The role of Fc-mediated immune responses in protecting against herpes zoster remains poorly understood. This study aimed to evaluate the Fc-mediated immune responses of anti-VZV glycoprotein E antibodies induced by two licensed varicella-zoster virus vaccines.We established two cohorts, each cons...

López-Dequidt I, Eiras-Penas S, González-Maestro A, Peña-Gil C, Rodríguez-Castro E, Santamaría-Cadavid M et al.

Cryptogenic stroke (CS) represents a heterogeneous group in terms of etiology. Atrial cardiopathy (AC) has emerged as a relevant underlying substrate for both stroke and atrial fibrillation (AF) in these patients. However, no reliable tools are currently available for the early and accurate ident...

Butt JH, Henderson AD, Jhund PS, Claggett BL, Desai AS, Borentain M et al.

The prevalence and prognostic significance of liver biomarkers in heart failure (HF) with mildly reduced or preserved ejection fraction are uncertain, with both potential hemodynamic and metabolic contributions to liver dysfunction in these patients. We evaluated the prevalence and prognostic val...

Ji B, Guo H, Xing R, Sun M, Cheng Y, Yao C et al.

Rationale: Macrophage phagocytosis is essential for pathogen clearance during sepsis. We previously demonstrated that the glycolytic enzyme 6-phosphofructokinase, muscle type (PFKM), modulates macrophage functions and its deficiency alleviates sepsis in mice. However, the function of PFKM in regu...

Hsiao FC, Hsu TJ, Hsieh YJ, Tung YC, Chen DY, Lin CP et al.

Patients with diabetes and a history of major adverse limb events (MALEs) are at an increased risk of cardiovascular and limb-related complications; however, effective glucose-lowering therapies for secondary prevention in this population are limited.To evaluate whether glucagon-like peptide-1 re...

Lee GH, Kim H, Moon HW, Yun YM, Lee S, Hur M et al.

Background and Objectives: Procalcitonin (PCT), presepsin (PSEP), interferon-λ3 (IFN-λ3), and bioactive adrenomedullin (bio-ADM) are promising sepsis biomarkers. We explored the clinical utility of a multi-marker approach using these four biomarkers in patients with suspected sepsis. ...

Bashir HH, Hasnain MA, Moon GS

Cutibacterium acnes resistance to antibiotics poses a significant challenge in treating acne vulgaris. Bacteriophages offer a promising alternative to overcome this challenge given their specificity. In the current study, 15 bacteriophages were isolated from acne affected volunteers and subjected...

Rai H, Singh R, Shankar G, Rai S, Kumar P, Nilakhe AS et al.

Alzheimer's disease (AD) remains a major unmet medical challenge, with limited tools that integrate early diagnosis and therapeutic intervention. Considering the pivotal roles of amyloid-β (Aβ) and cholinesterases (ChEs) in AD etiology, we report dual-functional theranostic NIR-I prob...

Avelar P, Morais TP, de Castro-Abrantes H, Armada-Moreira A, Gonçalves-Ribeiro J, Valente CA et al.

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that, through the activation of its full length receptor, TrkB-FL, plays a pivotal role in neuroprotection, namely against neuronal toxicity mediated by amyloid-β peptide (Aβ). In astrocytes, the increase of calcium (Ca2+) sig...

Ewees MGE, Abdelzaher LA, El-Shoura EAM, Abdel Rahman FES, Shabaan AM, Embaby MA et al.

Gentamicin (Genta) is a widely used aminoglycoside antibiotic, but its clinical value is limited by nephrotoxicity involving oxidative stress, inflammation, apoptosis, and dysregulation of the ADAM-17/ACE2/Ang (1-7)/MasR axis. β-Sitosterol (BSST) is a phytosterol with reported antioxidant a...

Zhang W, Liu H, Qian L, Zhang C, Wang D, Fang K et al.

Recent neuroimaging research emphasized cerebellar atrophy and alternation of functional connections in Alzheimer's disease (AD), fewer studies have focus on the cerebellar subfield and its structural network reorganization. This study aimed to explore the utility of 7 T MRI in assessing c...