Atosiban Research

Fitzek MP, Kleist P, Handtmann C, Overeem LH, Hoehne CL, Lange KS et al.

Oxytocin has been implicated in migraine pathophysiology through its roles in pain modulation and vascular regulation. Its receptors are present in migraine-related brain regions and cerebral vessels and interact with key migraine mediators such as calcitonin gene-related peptide (CGRP). Declinin...

van Gils L, van der Windt LI, van Kaam AH, Roos C, Pajkrt E, Oudijk MA et al.

Twin pregnancies have a substantial risk of preterm birth, but evidence on tocolytics is limited. We evaluated whether nifedipine or atosiban improves neonatal outcomes compared with placebo.Individual participant data network meta-analysis (IPD-NMA) of two international multicentre randomised co...

Zhong P, Chu B, Yu Z, Qiao Y, Ding Y, Zhang Y et al.

Arginine vasopressin (AVP) and oxytocin (OT) are peptide hormones critical for various physiological processes. Vasopressin receptor 1 A (V1aR), a primary AVP target, is promising for central nervous system (CNS) disorders therapies, yet the mechanisms of antagonism and oligomerization rem...

Schoep ME, Taken EMG, Nap AW, Nieboer TE

Li YX, Wei SQ, Zheng PS

Recurrent miscarriage (RM) remains a significant clinical challenge due to insufficient understanding of decidual microenvironment dysfunction and limited effective therapeutic options. Current treatments primarily focus on immunomodulation and hormonal therapy, which often fail to address the un...

Su Y, Guo Y, Ji H, Zhang M, Hou X, Ling X et al.

This retrospective study investigated factors associated with abnormal endometrial peristaltic waves (EPWs) and evaluated the impact of Atosiban intervention on clinical outcomes in frozen-thawed embryo transfer (FET) cycles. A total of 7,554 infertile women undergoing FET cycles were assessed us...

Canto-de-Souza L, Baptista-de-Souza D, Busnardo C, Crestani CC

We investigated the effect of systemic administration of the synthetic oxytocin (OXT) analog carbetocin and/or OXT receptor antagonists (atosiban and L-368,899) on social avoidance and anxiogenic-like effect in male rats subjected to chronic social defeat stress (cSDS). Effect of cSDS and pharmac...

Odendaal HJ, Lamont RF

Placental abruption is a significant cause of fetomaternal mortality/morbidity. Management requires a difficult balance between opposing advantages/disadvantages for the fetus and mother. Remote from term, prompt delivery is best for the mother, but delayed delivery better for the fetus.Prevalenc...

Pawlas J, Qvist T, Haugaard-Kedström LM

Universal Fmoc/t-Bu solid-phase peptide synthesis (SPPS) has long been intertwined with harmful substances such as dimethylformamide (DMF) and PFAS-classified trifluoroacetic acid (TFA). Having eliminated DMF and TFA from peptide synthesis by aqueous SPPS (ASPPS) [Pawlas, J.; Rasmussen, J. H. Cir...

Doret Dion M, Fendler A

Tocolysis is a tte gold standard in France in preterm labor before 34 WG. Nifedpine and atosiban are recommanded as first line tocolysis since the clinical guidelines published in 2016 by the French College of Obstetrics and Gynecology (CNGOF). Pregnancy prolongation over 48hours due to tocolysis...

van der Windt LI, Oudijk MA

Zegarra RR, Valentini B, Ghi T

Loussert L, Garabedian C, Dupuis N, Bujold E, Guerby P

Badshah M, Ibrahim J, Su N, Whiley P, Turpin-Nolan SM, Elnahriry KA et al.

Background/Objectives: Lower urinary tract symptoms (LUTS), such as frequency, urgency, nocturia, and urge incontinence, are commonly linked to overactive bladder (OAB) and benign prostatic hyperplasia (BPH). Oxytocin receptor (OXTR) upregulation has been proposed to enhance bladder and prostate ...

Shepperson OA, Malone MA, Arnott KIM, Brown RJ, Jamieson AG

We report an on-resin strategy for synthesizing 5-iodo-1,4-disubstituted-1,2,3-triazole-containing macrocyclic peptides as multifunctional disulfide bridge mimetics. Optimized Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and Suzuki-Miyaura conditions enabled late-stage arylation at the tria...

Pan L, Zhang N

Preterm births could increase the risk of neonatal conditions like cerebral palsy and neurodevelopmental delays. This trial aimed to evaluate the efficacy of magnesium sulfate and atosiban in providing neuroprotection to preterm infants. A clinical trial was conducted between 2020 and 2024, invol...

Chen H, Zou W, Xu X, Bian J

To investigate the role of a neural pathway from oxytocin (OXT) neurons in the paraventricular hypothalamic nucleus (PVN) to γ-aminobutyric acid (GABA) neurons (GABAergic neurons) in the trigeminal nucleus caudalis (TNC) in regulating pain sensitization in a mouse model of chronic migraine ...

Farsetti E, Amato S, Averna M, Guidolin D, Pedrazzi M, Maura G et al.

The ability of the neuropeptide oxytocin to affect glial cell function is receiving increasing attention. We previously reported that oxytocin at a low nanomolar concentration could inhibit both astrocytic Ca2+ signals and glutamate release. Here, we investigate the ability of oxytocin receptors ...

Chow LH, Chen YH, Chen YJ, Lin PC, Huang EY

Hyperalgesia is a clinical condition related to chronic pain in which patients experience increased nociceptive sensitivity. Intrathecal oxytocin has been shown to induce significant anti-hyperalgesia in both rodents and humans. However, in our previous studies, we demonstrated a clear sex differ...

Mol BW, Fatkullin I, Islamova L, Parizek A, Herman H, Janku P et al.

To assess the efficacy and safety of ebopiprant (OBE022), a novel, oral and selective prostaglandin F2α (PGF2α) receptor antagonist, to delay spontaneous preterm labor.This randomized, placebo-controlled, double-blind study (NCT03369262) was conducted between January 2019 and March 20...