Argireline Research

Zhu M, He X, Zhu Z, Lynch S, Wang H, Zhou X et al.

This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.In ex-vivo study, skin samples were expo...

Dikmen Kucuk S, Jabet P, Groso A, Collet G, Daniellou R, Karadeniz B et al.

The primary objective of this study was to investigate the biological activities of freeze-dried Ganoderma lucidum (Reishi) extract obtained from hazelnut pruning waste and to compare its antioxidant, tyrosinase inhibitory and cytotoxic properties with two widely used cosmetic actives-argireline ...

Feng M, Wu C, Jiang Y, Zhao C

This study developed a thermostable, high-loading dissolving microneedle (DMN) system for the transdermal delivery of anti-aging ingredients, 3-O-ethyl ascorbic acid (EAC) and acetyl hexapeptide-8 (AH-8). By using a composite matrix of hyaluronic acid (HA) and polyvinyl alcohol (PVA) in a 3:2 rat...

Rong G, Fan Q, Chen K, Cheng Y, Hu J

Peptides are increasingly recognized as important therapeutics due to their specificity and potency. However, their clinical application is often hindered by numerous barriers, including low bioavailability, poor cell membrane and tissue penetration. To address these limitations, we developed a l...

Xu Q, Li H, Zhao J, He X, Zhao L, Zhang X et al.

Postoperative infections and suboptimal scar outcomes remain persistent challenges in cosmetic surgery, impairing patient satisfaction and quality of life. This study evaluates whether a standardized fractional ultra-pulse CO₂ laser regimen can mitigate these complications.A multicenter re...

Moreno BA, Rodriguez-Puerto J, Haushalter K

Notalgia paresthetica (NP) is a chronic sensory neuropathy characterized by localized pruritus and dysesthesia of the upper back, typically resulting from thoracic dorsal rami entrapment. Treatment is often challenging, with many patients experiencing only partial relief from topical corticostero...

Ajdary N, Shafiee Ardestani M, Nequi Marnani H, Eshrati B, Zadeh Mehrizi T

The therapeutic application of Botox is limited due to its inherent structural instability, rapid degradation, and the need for frequent and painful injections. Since nanotechnology-based formulations could provide a solution to these problems, this study systematically investigated the developme...

Bates J, Liaw J, Girling K, Banks A, Gannon S, Earnshaw J et al.

Botulinum toxin type A is a potent neurotoxin and was first approved for use in 1989; since there has been a surge in its uses. The latest international trend is the unapproved use of botulinum toxin for allergic and nonallergic rhinitis, being advertised as "Haytox."A single-group open-label non...

Al-Haddab M, AlFada M, Alqubaisy Y, Alshahrani N, Alsufyani MA, Madani A et al.

The demand for botulinum toxin A (BTX-A) cosmetic treatments is growing among individuals with skin of color, primarily due to increased cultural acceptance, social media influence, and patient awareness. However, there remains a lack of standardized, evidence-based guidance on the use of BTX-A i...

Van Hout G, Vissers G, Tondu T, Thiessen F, Verhoeven V

This systematic review compared the effect of various topical analgesics on botulinum toxin injection pain perception. Data search was conducted in PubMed, Web of Science and the Cochrane Library up to 30 November 2024. Inclusion criteria were (1) research articles in English, Dutch, French or Ge...

Oad S, Qadir MU, Alam F, Jawed I, Jabeen S, Javaid M et al.

Acute anal fissure maintains a debilitating state that produces enduring wound damage on the anal mucosa while the internal anal sphincter demonstrates increased muscle tone. This study aims to conduct a comprehensive systematic review to evaluate the efficacy of botulinum toxin (BT) in the treat...

Chaijaras S, Boonpethkaew S, Chirasuthat S, Sakpuwadol N, Yongpisarn T, Anansiripun P et al.

Melasma management remains challenging due to its multifactorial nature pathogenesis and recurrent nature. Previous studies showed positive effects of botulinum toxin A (BoNT-A) for treating and preventing ultraviolet-induced hyperpigmentation.To evaluate the effectiveness of adjunctive incoBoNT-...

Yang X, Miao K, Chen Z, Meng Y, Xiang J, Chen C et al.

To overcome natural skin barrier, deliver ellagic acid (EA) to the dermis, and promote its anti-ageing efficacy, oligomeric hyaluronic acid (HA) modified EA-loaded liposomes (EA-HA-L) were constructed via self-synthesized different molecular weights of HA linked cholesterol (HA-Chol), and then th...

Johnson W, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD, Liebler DC et al.

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Acetyl Hexapeptide-8 Amide (synonymous with Acetyl Hexapeptide-8 (sans "Amide")) in cosmetic products; this ingredient is reported to function as a skin conditioning agent - miscellaneous in cosmetics. The Panel review...

Wang Z, Zhang L, Wang B, Wang M, Zhang J

This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery. The system alleviates dynamic wrinkles by inhibiting neurotransmitter release and repairs static wrin...

Hron T

Office-based laryngeal procedures comprise both diagnostic and therapeutic practices. They are an integral part of every laryngeal surgeon's practice. Topical anesthesia is utilized effectively along with anticipatory guidance and proper patient positioning to maximize patient comfort and increas...

Zdrada-Nowak J, Surgiel-Gemza A, Szatkowska M

Biomimetic peptides represent a growing class of active ingredients in modern cosmeceuticals, designed to mimic the function of the naturally occurring peptides involved in skin homeostasis, repair, and regeneration. Among them, acetyl hexapeptide-8 (AH-8), often referred to as a "botox-like" pep...

Wang M, Liu T, Wang H, Wang Z, Zhang J

The growing demand for safe and sustainable cosmetics has led to a marked inclination toward natural extracts and peptides as raw materials. In this study, we developed a sustainable system with multiple antiaging effects by combining peony extract (PE) and acetyl hexapeptide-8 (AHP8) to simultan...

Iraji F, Moeini R, Abedini M, Mousavi MS, Saber M, Barghani MRR et al.

Enlarged facial pores are a prevalent cosmetic concern affecting many individuals. Traditional treatments include topical agents and laser therapies, but recent advancements have introduced intradermal and microneedling-assisted Botulinum toxin type A (BoNTA) injections as promising alternatives....

Martin BA, Viegas J, Dalmolin LF, Santos ES, Vatanabe IP, Lisboa SF et al.

The skin is a complex organ composed of multiple layers and diverse cell types, including keratinocytes, fibroblasts, adipocytes, and sensory neurons, which maintain its structural and functional integrity together. Conventional in vitro and ex vivo models help investigate drug permeation and sel...