Apelin Research

Yao J, Li F, Hua X, Lu M

Non-alcoholic fatty liver disease (NAFLD), a chronic metabolic disorder characterized by ectopic lipid deposition in hepatocytes, currently lacks evidence-based pharmacotherapies, rendering probiotic-based strategies-particularly those utilizing Lactobacillus rhamnosus (LR)-a promising therapeuti...

Jiang J, Yang L, Cheng Y, Xiong M, Zhou X

An increase in glomerular endothelial cell (GEC) permeability is an early trigger for diabetic nephropathy (DN). This study investigated the protective role of the Apelin-36/APJ axis under diabetic conditions. In vitro, high glucose (HG) downregulated APJ expression and secretion of Apelin-36 in ...

Ozturk EK, Yilmaz MA, Sarioglu N, Hismiogullari AA

Xu X, Zhou L, Xie J, Li J, Guo C, Yang Z et al.

Rickettsia is an endosymbiotic bacterium that infects various arthropods, affecting the host's biology, ecology, and evolution. Leptocybe invasa is an invasive pest that severely damages eucalyptus plants. A comprehensive investigation of Rickettsia in 313 female L. invasa individuals from 17 Chi...

Szymańczyk S, Osiak-Wicha C, Kras K, Kapica M, Puzio I, Antushevich H et al.

Apelin is a postnatal peptide implicated in gastrointestinal maturation, yet its combined effects on mucosa, enteric plexuses, and gut-derived appetite signals are not well defined. We investigated the impact of chronic intragastric apelin-13 on the stomach and small intestine of unweaned rats. T...

Xi S, Ma J, Yan J, Li Y, Zhang P, Chen H et al.

Ischemic stroke (IS) persists as the second foremost cause of mortality and the primary cause of long-term disability globally, a burden largely attributable to a paucity of effective therapeutic strategies. Piperine (PIP) is a bioactive component of traditional Chinese medicine that has shown po...

Hoarau A, Frauenpreis A, Belgacemi R, Loeffler E, Maalouf O, Glass IA et al.

Single-cell RNA-sequencing analyses have revealed the existence of two distinct capillary cell populations in the human lung: general capillary cells (CAP1) and alveolar capillary cells (CAP2). Studies in mouse have shown that the splicing of Vegf-a evolves during embryonic development, creating ...

Hatch K, Murphy EK, Olson JD, Cole RN, O'Meally RN, Ingersoll RG et al.

Long-term neurological consequences of acute total-body γ-radiation are poorly understood. Here we have investigated the persistency of molecular changes in non-human primates (NHPs) more than five years after a single exposure to either a ~ 4Gy or ~ 8Gy dose.MS-based proteomic analyses wer...

Luna-Hernández A, Domínguez-Ordóñez R, García-Juárez M, Sánchez JLE, Tlachi-López JL, Pfaus JG et al.

The present study aimed to determine whether apelin-13 facilitates lordosis behavior through the activation of specific hypothalamic kinases and to identify which signaling pathways mediate this response. Because lordosis is a well-established neuroendocrine indicator of female sexual receptivity...

Stephan A, Graca FA, Poudel S, Fu Y, Wang YD, Labelle M et al.

Skeletal muscle wasting and weakness are prominent disease features. Originally considered to arise from common transcriptional changes, recent analyses demonstrated that different stimuli induce muscle wasting via largely distinct mRNA and protein changes.Here, we examined the post-translational...

Li Q, Song Y, Liu Q, Lin Z, Lin W, Huang F et al.

Deficiency in apelinergic signaling (APJ/Apelin) has been shown to accelerate cardiac aging. Given our observation that high-intensity interval training (HIIT) upregulates APJ and Apelin in aged mouse hearts, this study aimed to investigate whether apelinergic signaling mediates the cardioprotect...

Elsheikh A, Bist G, Kim S, Huang RY, Ruszaj D, Angevine D et al.

The apelin receptor (APJ) has emerged as a potential novel therapeutic target in cancer due to its role in regulating cell proliferation, angiogenesis, and metastasis. However, ML221, the only known selective small molecule APJ antagonist, exhibits poor plasma and liver microsomal stability, limi...

Li J, Lv X, Jiang Y

The aim of this study was to investigate the mechanism of action of SB on TRP-induced abnormalities of bone metabolism in LNCaP cells.The effects of different concentrations of SB and TRP alone and in combination on the proliferation of LNCaP cells were examined by CCK-8 assay, and the half maxim...

Liu S, Yang M, Wu S, Zhang D

Phacoemulsification combined with intraocular lens (IOL) implantation is the standard treatment for cataract. A proportion of patients still experience suboptimal visual outcomes or postoperative complications. This study aimed to investigate the roles of Interleukin-20 (IL-20) and Apelin-13 as b...

Krasniqi X, Jakupi X, Vincelj J, Gojani G, Çuni P, Shahini L et al.

Background: In patients with ST-segment elevation myocardial infarction (STEMI), apelin is upregulated and exerts cardioprotective effects against ischemia-reperfusion injury (IRI). The present study aimed to investigate serum apelin-36 levels in STEMI patients and their relationship with the no-...

Komić L, Komić J, Pavlović N, Kumrić M, Bukić J, Jerončić Tomić I et al.

Obesity, sarcopenia, and heart failure with preserved ejection fraction (HFpEF) constitute an interconnected clinical triad driven by multisystem mechanisms centered on the adipokine axis. Adipose tissue, now recognized as a dynamic endocrine organ, undergoes pathological remodeling in obesity, c...

Monteiro R

Cohen M, Weiss L, Weiss R, Shehadeh N, Khamaisi M

Background: Myokines are secreted by skeletal muscle and play a role in their metabolic function and crosstalk with various tissues. Myokines appear to be involved in the pathogenesis of obesity and type 2 diabetes (T2D), yet little is known regarding their function in type 1 diabetes (T1D). Aim:...

Perk P, Yuksel A, Dagdelen ZO, Mertoglu S, Cakmak M, Cennetoglu P et al.

Oruc KY, Oruc A, Arslan R, Diriarin FP, Mengi M, Tanriverdi G et al.

Glutamate-mediated excitotoxicity leads to mitochondrial dysfunction, apoptosis, and neuronal cell death. This study aims to investigate whether NPY2 receptors (NPY2R) and NPY5 receptors (NPY5R) enhance the effects of Apelin-13/APJ signaling pathways as modulatory cofactors in the neuroprotection...