Angiotensin-(1-7) Research

Lutshumba J, Mirsky E, Bullens KA, Smith EG, Ndashaala EL, Finch R et al.

Preeclampsia, a condition characterized by new-onset hypertension during pregnancy and ≥1 indices of organ damage, is a major driver of both short- and long-term maternal health outcomes. Individuals with a history of preeclampsia are at increased risk for cardiovascular, renal, and other ...

Singh G, Maparu K, Aran KR

Alzheimer's disease (AD) is characterized by progressive neurodegeneration marked by tau hyperphosphorylation, amyloid-beta (Aβ) buildup, neuroinflammation, and blood-brain barrier (BBB) dysfunction. Although much attention is paid to understanding amyloid and tau pathologies, there are sti...

Vernail VL, Mehay DL, Kimbark KD, Tanner JA, Bingaman SS, Silberman Y et al.

Angiotensin-(1-7) lowers blood pressure and improves metabolic outcomes in animal models of obesity and hypertension. Whether central mechanisms are involved in these protective cardiometabolic effects is poorly understood. In this study, we hypothesized that angiotensin-(1-7) engages central neu...

Xu Z, Li X, Wang S, Lyu J, Zhu S, Chen S et al.

Diminazene (DIZE), an agonist of the Ang-(1-7) system, has been proven to suppress astrocytic neuroinflammatory responses in Alzheimer's disease (AD). NADPH oxidase 4 (NOX4) is abundantly expressed in astrocytes and critically mediates oxidative stress damage and ferroptosis. However, the mode of...

Natarajan B, Vijayakumar A, Iyer DR, Venkatraman J, Arige V, Khan AA et al.

Manifesting initially as a physiological adaptation to pressure/volume overload, cardiac hypertrophy helps to maintain normal cardiac output via optimal mitochondrial function. However, chronic hypertension leads to pathological cardiac hypertrophy that is characterized by compromised cardiac out...

Eleuteri D, Del Tedesco F, Silvia F, Tucciariello C, Ruggiero E, Gervasoni J et al.

The renin-angiotensin system (RAS) plays a critical role in vascular homeostasis and inflammation, and its dysregulation has been implicated in the pathophysiology of COVID-19. We investigated the dynamics of RAS peptides and markers of endothelial dysfunction in relation to respiratory disease p...

Alves DT, Nickl B, Qadri F, Santos RA, Santos SH, Gollasch M et al.

This study explores the anatomical distribution of Angiotensin-(Ang)-(1-7) fusion protein within the central nervous system of the novel transgenic rat model (TG7371). The Ang-(1-7)/Mas pathway of the renin-angiotensin system (RAS) plays a key role in cardiovascular regulation and influences high...

Zhang W, Jiang X, Wang M, Li W, Zhao Q, Guan H et al.

Hypertension, a major global health issue, is closely associated with the overactivation of angiotensin-converting enzyme (ACE). Food-derived ACE inhibitory peptides are gaining increasing attention as natural alternatives to synthetic antihypertensive drugs due to their safety and efficacy. In t...

Bai HJ, Wang YW, Li ZQ, Lu DX, Nan XM, Yang ZT et al.

Hypoxia induced-pulmonary hypertension (HPH) is a life-threatening cardiovascular disorder prevalent in high-altitude regions. Right ventricular (RV) function and RV—pulmonary arterial (RV—PA) coupling are key to patient prognosis. Perillyl alcohol (POH), a natural compound, holds p...

Bilgin E, Haznedaroğlu İC

The renin-angiotensin system (RAS), traditionally regarded as a hormonal cascade regulating cardiovascular and renal homeostasis, is increasingly recognized as a locally active, tissue-specific network within joint structures. Accumulating evidence indicates that synovial tissue, synovial fluid, ...

Aazar RFM, Arzouni R, Nicolaou PA

Overactivation of the renin-angiotensin-aldosterone system (RAAS) promotes haemodynamic overload, inflammation, and fibrosis in the heart and kidneys. Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors have emerged as a cornerstone therapy in cardiorenal protection. Emerging data indicat...

Ewees MGE, Abdelzaher LA, El-Shoura EAM, Abdel Rahman FES, Shabaan AM, Embaby MA et al.

Gentamicin (Genta) is a widely used aminoglycoside antibiotic, but its clinical value is limited by nephrotoxicity involving oxidative stress, inflammation, apoptosis, and dysregulation of the ADAM-17/ACE2/Ang (1-7)/MasR axis. β-Sitosterol (BSST) is a phytosterol with reported antioxidant a...

Melo-Braga MN, Magalhães GC, Silva FA, Kjeldsen F, Larsen MR, Santos RAS et al.

Angiotensin-(1-7) [Ang-(1-7)] is a heptapeptide of the renin-angiotensin system (RAS) with antitumoral effects reported in various tumoral cell lines, including the human lung adenocarcinoma A549 lineage. While previous studies have shown that Ang-(1-7) modulates MAPK and PI3K-AKT signaling, the ...

Pedoto A, Lozano-Gil JM, Ocaña-Esparza M, Conesa-Hernández AM, Candel S, Cayuela ML et al.

Since the emergence of SARS-CoV-2 in late 2019, substantial efforts have been made to understand its mechanisms of pathogenicity. Although angiotensin-converting enzyme 2 (ACE2) has been identified as the main receptor for viral entry, the complexity of the host immune response to different Spike...

Ashaolu TJ

Food-derived bioactive peptides are gaining significant attention as safer, natural alternatives to synthetic drugs for managing hypertension. While research has predominantly focused on angiotensin-converting enzyme (ACE) inhibition, the frequent disconnect between in vitro potency and in vivo e...

Pan X, Shao Y, Wu F, Wang Y, Xiong R, Zheng J et al.

Paulis L, Rajkovicova R, Repova K, Gubo G, Barta A, Poglitsch M et al.

Combined renin-angiotensin system (RAS) inhibition can enhance blood pressure control but has not improved clinical outcomes, underscoring the importance of complex changes in angiotensin peptide profiles in combined RAS blockade. We investigated hemodynamics and circulating and tissue angiotensi...

Pechanova O, Paulis L

SARS-CoV-2 engages ACE2 for cell entry, perturbing the counter-regulatory ACE2/Ang-(1-7)/Mas axis and shifting the renin angiotensin system toward ACE/Ang II/AT1 signaling, with a concomitant reduction in nitric oxide (NO) bioavailability. NO sits at the crossroads of these pathways, acting both ...

Lange-Tal T, Tuvia N, Lazar S, Farajh Y, Bernstine T, Abassi Z et al.

Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin aldosterone system (RAAS), is the main receptor for SARS-CoV-2 entry into human cells. The occurrence of long-term symptoms post-COVID 19 infection (Long COVID, LC) is an important public health issue with an unclear eti...

Niu Q, Wang T, Li J, Zhao L, Cai J

Non-alcoholic fatty liver disease (NAFLD) is a global health burden characterized by hepatic steatosis and progressive fibrosis, necessitating novel therapeutic strategies. This study investigates the molecular mechanism by which cyclic RGD peptide (cRGD)-modified adipose-derived mesenchymal stem...