Amylin Research

Secher A, Lutz TA, Raun K

Amylin is a glucoregulatory peptide hormone discovered in 1986. Almost 20 years later, pramlintide, a human amylin analogue, emerged as the first amylin-based drug, approved as an adjunct treatment to insulin for type 1 diabetes (T1D) and type 2 diabetes (T2D). Despite its effects on multiple org...

Li Y, Dong R, Liu X, Yuan Y, Kong Y

Modern medical imaging provides important insights into brain network analysis. Functional brain networks are used to characterize the functional connectivity patterns in resting or task states, and structural brain networks reflect the integrity and connectivity strength of macro-scale pathways....

Hu Z, Kang J, Lin N, Chen H, Liu F, Li J et al.

The residual bacteria in bacteriophage (phage) preparations have hindered their application in poultry disease. We isolated eight phages from aquatic environment samples and selected two phages (vB_StyS_SP03 and vB_StyM_SP07) for amplification using the diaminopimelic acid (DAP)-dependent Salmone...

Alhalabi H, Borschel L, Le Foll C, Thomas A, Bally L, Thevis M et al.

Peptide hormone-based weight-loss therapeutics have gained increasing attention, driven amongst other reasons, by the clinical and commercial success of semaglutide. Their increasing accessibility raises concerns about their potential misuse in sports, especially in disciplines where weight manag...

Wang Y, Bullard KM, Zhang P

Expenditures on glucose-lowering prescriptions may have changed because of the introduction of new medication classes and changes in insurance policies. This study analyzed national trends in per capita expenditures on glucose-lowering medications among U.S. adults with diabetes during 2000-2022....

Liang W, Zheng S, Shalliker RA, Doonan C, Li F

Efficient biocascades require integrated optimization of both biocatalysts and reaction conditions. In the present study, we employ a Latin hypercube sampling-coupled Bayesian optimization (LHS-BO) workflow to sequentially optimizes multivariate Zr-based E-MOF (E-MOF = enzyme@metal-organic framew...

Pocevičiūtė D, Roth B, Olofsson A, Hansson O, Wennström M

The efficient clearance of IAPP oligomers (IAPPo) by autoantibodies is crucial as increased plasma levels of IAPPo can induce microvascular alterations and Alzheimer's disease (AD)-characteristic amyloid-β deposition in the brain. We have recently demonstrated that plasma immunoglobulin (Ig...

Prapan A, Poontein C, Pongsar C, Chobdee K, Sang-Ondee P, Pengpan T et al.

Scatter radiation in mobile chest radiography reduces image contrast and diagnostic confidence. Although physical grids improve image quality, they increase radiation dose and require precise alignment. Software-based scatter correction offers a potential alternative, but its performance across v...

Vasilevsky N, Gehrke S, Mullen K, Barua S, Braun I, Brünger T et al.

Epilepsy is a diverse group of neurological disorders affecting over 50 million people worldwide. While common epilepsy types are well studied, rare epilepsies-often severe and genetically complex-pose significant challenges in diagnosis, research, and treatment. Accurate and interoperable etiolo...

Xing Y, Zhang W, Yang Z, Qin X, Zhou T, Zhang N et al.

Amylin is a hormone secreted by pancreatic β cells, and oligomerized human amylin (hAmylin) has shown neurotoxicity in mice. However, the effect of hAmylin oligomers on cognitive ability and the underlying mechanisms remains unexplored.In this study, hAmylin oligomers were bilaterally injec...

Patel RS, Chavda PA, Thakker ZG, Patel DH, Panchal MK, Patel RV et al.

Fluorescent supramolecular materials have emerged as versatile tools for detecting nitroaromatic compounds (NACs), which are key components of explosives and persistent environmental pollutants. Among these analytes, 2-nitrobenzaldehyde (2-NBZ) warrants particular attention due to its high toxici...

Xu T, Zhang Y, Zhang Y, Huang Q, Wang M, Yang J et al.

Drought stress severely limits maize growth, and enhancing drought resistance remains a central objective of crop improvement. Plant-specific NAC (NAM/ATAF/CUC) transcription factors are critical regulators of abiotic stress responses. Previously, we identified ZmNAC20-a gene rapidly induced by b...

Wang X, Li S, Zhang S, Sun Q, Cheng Q, Bao K et al.

Ascorbic acid (AA) and alkaline phosphatase (ALP) are essential biomolecules involved in numerous physiological and pathological processes. However, conventional nanozyme assays based on AA reduction or ALP-mediated AA generation often suffer from interference from coexisting reductants, compromi...

Wang M, Xu J, Lyu Y, Luo M, Sun Y, Ye S et al.

Improving phosphorus (P)-use efficiency (PUE) while increasing crop yield is one of the greatest challenges in sustainable P management for sustainable agriculture. Types of P fertilizers and soil water supply impact P availability and crop growth, but how to optimize P fertilizer and water suppl...

Yu M, Wang J, Zhou R, Yan J, Jiang H

Difficult mask ventilation (DMV) poses significant perioperative challenges, particularly in oral and maxillofacial surgery. Maxillofacial computed tomography (CT) imaging may offer improved airway assessment. This study aimed to identify those preoperative midsagittal CT parameters associated wi...

Maksoud Z, Köhler M, Nacul Mora G, Möllmann F, Masthoff M, Eßeling R et al.

Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment for complications of portal hypertension; yet the influence of anesthesia modality on procedural performance and hemodynamics remains insufficiently characterized. This retrospective single-center study compared radi...

Zhang N, Zhang X, Guo Y, Zheng Y, Gai W, Zhu B et al.

Drowning-associated pneumonia (DAP) is the most common infectious complication in drowning patients admitted to the pediatric intensive care unit (PICU). We aim to describe the clinical features, emergency interventions, microbiological characteristics, and antibacterial treatment strategies for ...

DeWolf EL, Webber B, Webber MJ

Biologic therapies for diabetes have advanced significantly through molecular engineering strategies that optimize therapeutic stability, pharmacokinetics, and delivery. This review presents an integrated overview of design principles used to develop insulin, glucagon, amylin analogs, and GLP-1 r...

Satyana Karyawati A, Dharmawan D, Rahmadillah H, Waluyo B, Ula VM

Fall armyworm (Spodoptera frugiperda) is a major invasive pest threatening soybean production, and identifying resistant genotypes is essential for sustainable crop protection. This study evaluated 36 soybean genotypes for their resistance to S. frugiperda based on leaf damage intensity and frequ...

Ma X, Yuan D, Zi Y, Chen J, Zhang J, Tan X et al.

Camellia oleifera Abel. is an important woody oil tree species in China, and increasing the content of polyunsaturated fatty acids (PUFAs), particularly α-linolenic acid (ALA), is critical for improving the quality of its oil. Fatty acid desaturase 7 (FAD7) is a key enzyme in ALA biosynthes...