Adrenomedullin Research

Apostolopoulos Y

Truck drivers sustain the movement of goods across Europe, yet the sector faces a concurrent health and workforce retention crisis-mirroring trends observed in North America. Approximately 426,000 driver positions remain unfilled across Europe, while rates of fatigue, sleep disruption, obesity, d...

Rodrigues PDC, Myrdek T, Ferreira GA

The combination of cellulose nanocrystals (CNC) and anionic alkyl poly(ether) carboxylate surfactants offers a sustainable approach to modulating the interfacial and foaming properties of aqueous systems. This study investigated CNC-surfactant interactions in bulk and at the air-water interface u...

Mehta C, Has P, Mehta A, Vargas I, Osorio B, Shin A et al.

There are limited data on the etiology, management, and outcomes of Society for Cardiovascular Angiography and Interventions (SCAI) B cardiogenic shock.From 2017 to 2022, adult patients (≥18 years) admitted to the medical, intermediate, and critical care units in a 6-hospital system were e...

Batty LM, Huynh M, Webster KE, Vassileff N, Spiers JG, Klemm HJ et al.

The risk of posttraumatic arthritis is elevated after anterior cruciate ligament (ACL) injury, and this can influence follow-up patient-reported outcome measures (PROMs). Biomarkers of chondral and matrix metabolism may represent a means of quantitatively evaluating the posttraumatic arthritis pa...

Van Wauwe J, Janarthanan P, Craps S, Kc A, Asuncion L, Vrancaert P et al.

TF (transcription factor) Prdm16 (positive regulatory domain-containing protein 16) regulates hematopoietic and neuronal stem cell homeostasis, adipose differentiation, and cardiac development. Its role in the circulatory system extends beyond the heart, as Prdm16 loss in arterial endothelial cel...

Shi G, Xu L, Deng L

Deuterated compounds are of significant interest in chemistry, medicinal chemistry, and the pharmaceutical industry. Herein, we report organocatalytic isomerization-deuteration reactions of trifluoromethyl imines via a deprotonation-H/D exchange-deuteration sequence, providing a new strategy for ...

Huang K, Cai H, Hong Y, Wu L, Bao J, Jiang C et al.

Osteoarthritis (OA) involves progressive cartilage degradation, and the extracellular matrix (ECM) regulates chondrocyte behavior. In OA, ECM stiffening, driven by age-related matrix changes and mechanical joint injuries, contributes to cartilage damage. Although RhoA/ROCK and ERK1/2 signaling pa...

Jiao A, Gautam S, Pandey J, Scheuring DC, Koym JW, Vales MI et al.

Upon harvest, potato (Solanum tuberosum L.) tubers enter a dormant state and do not sprout even under favorable conditions. Early dormancy break causes tuber spoilage and reduces postharvest quality. Common sprout control methods may compromise tuber quality, raise health and environmental concer...

Banys-Paluchowski M, Lüftner D, Korfel A, Chouaki N, Sanderson I, Barlow SG et al.

This study evaluated the experiences of patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative early-stage breast cancer (EBC) in France, Germany, Italy, Spain, and the UK, including satisfaction with how well they are coping with their EBC, their wellbeing, kn...

Quirós RE, Araujo JS, Macchi A, Di Libero E, Teruel M, Maldonado MF et al.

Antimicrobial resistance (AMR) is a major global health threat, with a disproportionate impact on low- and middle-income countries. The TEACH PROA-ECHO (Telementoring, Equity & Advocacy Collaboration for Health through Antimicrobial Stewardship) initiative aimed to strengthen antimicrobial st...

Rafehi M, Tägl F, Arlt NS, Neif M, Stefan K, Ismail Al-Khalil W et al.

Altogether, 60-70% of the ATP-binding cassette (ABC) and solute carrier (SLC) transporters can currently not be targeted by drugs, despite their involvement in human diseases. The design of potential drug candidates relies on hit identification and subsequent optimization with regard to selectivi...

Erhie E

Two preventable trauma deaths during my medical training in Lagos, an eight-year-old boy, with a splenic injury and a mother struck by a truck, revealed a devastating truth: in many settings, treatable injuries become fatal because trauma systems fail to respond fast enough. These losses, compoun...

Eeckhoudt J, Dellwisch A, Plump A, Zeller F, Neudecker T, De Proft F et al.

Aromaticity is a fundamental concept in chemistry, central to understanding chemical stability, reactivity, and electronic structure. While traditionally examined under ambient conditions, recent studies have begun to probe its behavior in unconventional regimes, reflecting the diversification of...

Tanas Y, Harris P, Gasper G, Cato L, Cervantes Valadez S, Rashidi K et al.

AlloDerm and Cortiva are 2 commonly used human acellular dermal matrices for prosthetic breast reconstruction, yet their comparative clinical performance remains uncertain. The objective of this study is to systematically compare short-term clinical outcomes, patient-reported physical well-being,...

Toth C, Campbell BA, Bocca LF, Baker K, Hogue O, Tiefenbach J et al.

Subthalamic nucleus deep brain stimulation (STN-DBS) is a standard-of-care (SoC) treatment for the motor symptoms of Parkinson's disease (PD); however, how therapeutic DBS influences motor output is incompletely understood. Specifically, the extent of electromyographic (EMG) modulation during DBS...

Ye L, Peng L, Tian J, Ma H

Puerarin is a flavonoid bioactive component extracted from the Chinese herb radix puerariae, which has been reported to have anti-inflammatory and neuroprotective effects and is a potential drug for the treatment of neuroinflammatory diseases. There is increasing evidence that the gut-liver-brain...

Farkowski MM, Szmit S, Boriani G, Castrejon S, Fradley M, Guha A et al.

This study aimed to assess current clinical practices in the diagnosis and management of atrial fibrillation (AF) among patients with active cancer or a history of cancer therapy.A 25-item, physician-based survey was developed by the European Heart Rhythm Association in collaboration with the Eur...

Guo Q, Wang S, Li J, Jiang Y, Zhang Z, Sasase M et al.

Catalytic ammonia decomposition for hydrogen release at reduced temperatures is a critical component of the hydrogen energy roadmap. However, conventional nonprecious transition metal (TM) catalysts, such as Ni and Co, typically suffer from a high energy barrier in the N-N coupling step. In this ...

Santunione AL, Camatti J, Radheshi E, Cecchi R

Mechanical asphyxia is well documented in forensic pathology; however, deaths resulting from the simultaneous action of distinct asphyxial mechanisms remain uncommon and challenging to interpret. We report a case of homicidal asphyxia in a 20-year-old man in whom smothering, ligature strangulatio...

Zhao H, Wang X, Ye H, Lum LYX, Wang X, Ho JY et al.

Achieving long-term stable dropwise condensation in industry has been a long-standing goal over the past few decades. However, due to irreversible wetting state transition and insufficient material durability, the delicate dropwise condensation (DWC) mode rapidly deteriorates to the filmwise cond...