Actovegin Research

Hassø RK, Lindtofte S, Kosik B, Bergdahl A, Larsen S

Zein NS, El Moshy S, Khashaba M, El-Maghraby EMF, Rashed ER, Abdel-Hamid DM et al.

Evaluating the effect of synthetic nano-hydroxyapatite/silica gel bone substitute and/or hemodialysate on gamma irradiated bone regeneration and bone nano-mechanical properties in rat model.Seventy adult male Wistar albino rats (total of 70 defects, 1 defect/rat) were randomly divided into five g...

Hamid A, Chong PL, Khor YY, Kong PY, Rasli NR, Abd Warif NM et al.

Research on plant-based wound healing agents has been one of the current developing areas in modern biomedical science. This study aimed to assess the effects of ethyl acetate extract of Zingiber zerumbet rhizome (ZZRE) on open wound healing activity in Wistar rats. Ninety male Wistar rats (220-3...

Milovanović D, Radovanović D, Živković V, Srejović I, Glišić M, Jakovljević V et al.

Evidence regarding the performance-related effects of Actovegin is limited, despite legislated restrictions being in place for this supplement within sport settings.Our study examined the effects of Actovegin on physiological responses and performance during maximal cardiopulmonary exercise in co...

Abdul Latif M, Mustafa A, Keong LC, Hamid A

The objective is to investigate the healing efficacy of a Chromolaena odorata layered-nitrile rubber transdermal patch on excision wound healing in rats. Wounds were induced in Sprague-Dawley rats and were later treated as follows: wound A, the negative control, received no treatment (NC); wound ...

Al-Nadaf AH, Awadallah A, Thiab S

The process of wound healing is complicated. Antimicrobial silver has been one of the substances used for wounds since ancient times. Moreover, traditional medicine has long used Juglans regia L. to promote wound healing. Since eco-friendly nanotechnology has various uses in biomedical research, ...

Ziegler D

Diabetic peripheral neuropathy (DPN) is found in around one third of people with diabetes, but remains inadequately diagnosed and treated. Its management includes three cornerstones: 1) causal treatment with lifestyle modification, intensive diabetes therapy aimed at near-normoglycemia, and multi...

Boksha I, Savushkina O, Sheshenin V, Tereshkina E, Prokhorova T, Pochueva V et al.

A number of studies have shown the feasibility of using adjunctive drugs in late onset psychosis (LOP).Testing hypothesis that among LOP people treated with antipsychotics and antidepressants, basing on certain clinical characteristics a subgroup of patients might be distinguished, for whom adjun...

Grigoryan MZ, Kazumyan SV, Makeeva MK, Arzukanyan AV, Khabadze ZS, Sokhova IA et al.

The purpose of this study was to evaluate the duration of fixation of adhesive films in the treatment of traumatic lesions of the oral mucosa.The patients were divided into 2 groups. In the first group, the affected area was covered with an adhesive film with solcoseryl, in the second group with ...

Kosik B, Larsen S, Bergdahl A

Insulin deficiency in type 1 diabetes (T1D) leads to an impairment of glucose metabolism and mitochondrial function. Actovegin is a hemodialysate of calf blood, which has been shown to enhance glucose uptake and cell metabolism in healthy human skeletal muscle. The objectives of this study were t...

Li Y, Cui R, Liu S, Qin Z, Sun W, Cheng Y et al.

Background: Stroke survivors are at significantly increased risk of cognitive impairment, which affects patients' independence of activities of daily living (ADLs), social engagement, and neurological function deficit. Many studies have been done to evaluate the efficacy and safety of post-stroke...

Anghelescu A, Firan FC, Onose G, Munteanu C, Trandafir AI, Ciobanu I et al.

Stroke is a significant public health problem and a leading cause of death and long-term disability worldwide. Several treatments for ischemic stroke have been developed, but these treatments have limited effectiveness. One potential treatment for this condition is Actovegin®/AODEJIN, a calf...

Song MS, Ku YA, Kim S, Chung MH, Kim YH, Kim DH et al.

To compare the corneal epithelial wound healing effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN) in a rat alkali burn model.In 40 male Sprague-Dawley rats, we induced alkali burn using filter paper soaked in 0.2N sodium hydroxide. The rats were then treated with topical 0.5% RCI0...

Suchkov IA, Mzhavanadze ND, Bogachev VY, Bokuchava M, Kuznetsov MR, Lukyanov YV et al.

This study aimed to assess the efficacy and safety of Actovegin for the treatment of patients with Fontaine stage IIB peripheral arterial disease (PAD).The study included 366 patients with Fontaine stage IIB PAD from 19 centers (Russia, Georgia, Kazakhstan). Placebo or Actovegin (1200 mg daily [Q...

la Fleur P, Baizhaxynova A, Reynen E, Kaunelis D, Galiyeva D

Actovegin is a hemodialysate of calf's blood and has been used for several decades in the countries of Central Asia, East Asia, Russia and some European countries. It has been used to treat patients with various neurological conditions, vascular disorders, and ischemic stroke.To perform a systema...

Pavliuk B, Stechyshyn I, Kramar S, Chubka M, Hroshovyi T

Due to the problem of treating some types of burns, it is necessary to develop new drugs. For this purpose, pharmacological studies of developed gel "Xeliogel" (based on biological material with regenerating action), which accelerates the healing of superficial burns, have been developed and prev...

Reichl FX, Högg C, Liu F, Schwarz M, Teupser D, Hickel R et al.

Martí-Carvajal AJ, Knight-Madden JM, Martinez-Zapata MJ

The frequency of skin ulceration makes an important contributor to the morbidity burden in people with sickle cell disease. Many treatment options are available to the healthcare professional, although it is uncertain which treatments have been assessed for effectiveness in people with sickle cel...

Li W, Guo A, Sun M, Wang J, Wang Q

Deproteinized calf serum (DCS) may have neuroprotective effects after ischemic stroke. The aim of this study is to investigate whether and how the DCS inhibits neuronal injury following cerebral ischemia. Rats were subjected to 2 h transient middle cerebral artery occlusion (MCAO). One dose of 0....

Kurkin DV, Morkovin EI, Kalatanova AV, Bakulin DA, Verholyak DV, Kovalev NS et al.

To compare the antioxidant effects of cortexin, cerebrolysin and actovegin in rats with chronic brain ischemia.Chronic brain ischemia was modeled in male rats by 50% stenosis of the common carotid arteries. Forty days after surgery, the animals received 2 ten-day courses of therapy, separated by ...