Acetyl Tetrapeptide-5 Research

Liu J, Pei Y, Huang Y, Jiang H, Tadoh MPT, Huang X et al.

Edema of the prepuce is a common clinical complication following circumcision in urology. Nevertheless, the principal method of gauze wrapping in clinical practice has not yet been demonstrated to be an effective solution to the problem of postoperative edema. It is therefore evident that the dev...

Liu Y, Xu T, Ma Z, Zhang C, Xu M, Li Q et al.

Preventing joint edema is crucial in halting osteoarthritis (OA) progression. Growing clinical evidence indicate that Jianpi-Tongluo Formula (JTF) may have a promising anti-edema effect. However, the therapeutic properties of JTF and the underlying mechanisms remains unclear.An OA rat model was e...

Yu H, Yan S, Jin M, Wei Y, Zhao L, Cheng J et al.

Non-alcoholic fatty liver disease (NAFLD) is a common metabolic liver disease worldwide. It has been proven that aescin (Aes), a bioactive compound derived from the ripe dried fruit of Aesculus chinensis Bunge, has a number of physiologically active properties like anti-inflammatory and anti-edem...

Ozdemir A, Ogden M, Kartal B, Ceylan AF, Yuksel U, Bakar B et al.

Cerebral stroke is a serious clinical condition in which oxidative stress, inflammation, necrosis, apoptosis, and autophagy play important roles in its pathogenesis. This study investigated the neuroprotective and healing effects of calcium dobesilate (CD) on cerebral hypoxia/reperfusion injury i...

Abebe EC, Mengstie MA, Seid MA, Malik T, Dejenie TA

Alarin is a member of the galanin family of neuropeptides that is widely expressed in the central nervous system and peripheral tissues in humans and rodents. It was initially isolated fifteen years ago in ganglionic cells of human neuroblastoma. Subsequently, it was demonstrated to be broadly di...

Rioux B, Combes J, Woolley JM, Rodrigues NDN, Mention MM, Stavros VG et al.

Although organic UV-filters are extensively used in cosmetics to protect consumers from the deleterious effects of solar UV radiation-exposure, they suffer from some major drawbacks such as their fossil origin and their toxicity to both humans and the environment. Thus, finding sustainable and no...

Mert I, Cetinkaya A, Gurler M, Turel CA, Celik H, Torun IE et al.

The present study aimed to explore the possible anti-inflammatory actions of liraglutide (LRG), a glucagon-like peptide-1 (GLP-1) receptor agonist, and to compare with tramadol (TR) or LRG, and TR combination treatment by investigating the inflammatory signs such as pain hypersensitivity, edema, ...

Papamichael D, Lopes GS, Olswold CL, Douillard JY, Adams RA, Maughan TS et al.

Colorectal cancer (CRC) affects many older adults. We investigated the efficacy and safety of adding anti-epidermal growth factor receptor (EGFR) agents to doublet chemotherapy (DC) in older patients.Patients with RAS wild-type (WT) metastatic CRC (mCRC) receiving first-line DC + anti-E...

Rodrigues NDN, Woolley JM, Krokidi KM, Tesa-Serrate MA, Turner MAP, Hine NDM et al.

The negative effects of ultraviolet radiation (UVR) on human skin have led to the widespread use of sunscreens, i.e. skincare products containing UV filters to absorb, reflect or otherwise block UVR. The mechanisms by which UV filters dissipate energy following photoexcitation, i.e. their photody...

Wu Y, Cao K, Zhang W, Zhang G, Zhou M

Skin aging usually leads to the excessive deterioration of the dermal extracellular matrix, loss of antimicrobial function, loss of skin barrier function, and a series of inflammatory processes. Bioactive peptides have been widely used in cosmetics due to their protective effects on skin and effi...

Fang Y, Shi H, Ren R, Huang L, Okada T, Lenahan C et al.

Brain edema is a vital contributor to early brain injury after subarachnoid hemorrhage (SAH), which is responsible for prolonged hospitalization and poor outcomes. Pharmacological therapeutic targets on edema formation have been the focus of research for decades. Pituitary adenylate cyclase-activ...

Alexandri M, Blanco-Catalá J, Schneider R, Turon X, Venus J

The biotechnological production of platform chemicals from renewable resources is in the scientific spotlight, as researchers seek to develop environmentally friendly and cost-efficient processes to compete with the petroleum-based ones. Lactic acid (LA) is an established platform chemical, regis...

Ma J, Zhang S, Liu J, Liu F, Du F, Li M et al.

Cell membrane coating has recently emerged as a promising biomimetic approach to engineering nanoparticles (NPs) for targeted drug delivery. However, simple cell membrane coating may not meet the need for efficient drug delivery to the brain. Here, a novel molecular engineering strategy to modify...

Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L et al.

Polydatin is a glucoside of resveratrol with lots of functional properties in the central nervous system, such as anti-edema, anti-oxidation and anti-inflammation. The purpose of this study was to evaluate the effects of polydatin on traumatic spinal cord injury (SCI) and explore the relative mec...

Kobiela T, Milner-Krawczyk M, Pasikowska-Piwko M, Bobecka-Wesołowska K, Eris I, Święszkowski W et al.

Atomic force microscopy (AFM) and fluorescence microscopy was applied to determine the influence of the anti-aging peptides on the morphology and the mechanical properties of keratinocytes. Immortalized human keratinocytes (HaCaT) were treated with two anti-aging bioactive peptides: Acetyl Tetrap...

Rafferty DW, Dupin L, Zellia J, Giovannitti-Jensen A

Sensory perceptions and performance are important to the success of a lipstick formulation, but in vivo evaluation can be expensive and time-consuming. The goal of this work was to develop and use laboratory test methods to predict the sensory and performance properties of lipstick.Twelve mo...

Park SM, Lee TH, Zhao R, Kim YS, Jung JY, Park CA et al.

Socheongryong-Tang (SCRT) is a natural medicine prescription that has been mainly used in East Asia for the treatment of inflammatory disorders, including asthma and allergic rhinitis. The present study evaluated the anti-inflammatory effects of SCRT on lipopolysaccharide (LPS)-stimulated RAW 264...

Park SM, Min BG, Jung JY, Jegal KH, Lee CW, Kim KY et al.

Pelargonium sidoides (PS) and Coptis chinensis root (CR) have traditionally been used to treat various diseases, including respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders. The present study was conducted to evaluate the anti-inflammatory effects of a combination o...

Sugimoto MA, de Jesus Amazonas da Silva M, Froede Brito L, Dos Santos Borges R, Amaral FA, de Araujo Boleti AP et al.

Inflammation is a reaction of the host to infectious or sterile stimuli and has the physiological purpose of restoring tissue homeostasis. However, uncontrolled or unresolved inflammation can lead to tissue damage, giving rise to a plethora of chronic inflammatory diseases, including metabolic sy...

Oh YC, Jeong YH, Cho WK, Hwang YH, Ma JY

Dianthi Herba is a traditional herbal medicine used to treat inflammatory-related diseases including acute pyelonephritis, cystitis, laryngopharyngitis, and urethritis.We investigated the effects of Dianthi Herba ethanolic extract (DH) on lipopolysaccharide (LPS)-mediated inflammatory responses i...