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Dosage GuideResearch Reference

Semax Dosage

Research-based dosing protocols, timing guidance, and reconstitution reference for Semax. All information is for educational purposes only.

Quick Answer

Typical Semax dosages range from 200-2000 mcg per day, administered intranasally or subcutaneously. Intranasal administration is most common due to ease of use and direct access to the brain. Dosage depends on indication and individual response. Start low and titrate up as needed. No formal dose-ranging human clinical trials have been completed.

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Table of Contents

Standard Dosage Range

Research dosing range: 200–2000 mcg per day

Educational reference only

These dosage ranges are derived from preclinical research and community protocols. No human clinical dose-ranging trials have established therapeutic doses for most research peptides. Always consult a qualified healthcare provider before starting any peptide protocol.

Dosage by Use Case

Cognitive Enhancement

200-1000 mcg1-2× daily
Duration

2-8 weeks

Intranasal administration. Divide daily dosage into 1-2 administrations. Some users prefer morning dosing to avoid sleep disturbances.

Post-Stroke Recovery

500-2000 mcg1-2× daily
Duration

4-12 weeks

Subcutaneous or intranasal. Higher doses may be used in acute stages, tapering down as recovery progresses. Requires careful monitoring by a physician.

Optic Nerve Disease

300-1000 mcg1× daily
Duration

4-8 weeks

Intranasal administration. Studies suggest benefits in glaucoma-related neuropathy and optic nerve damage.

ADHD Symptoms

200-750 mcg1-2x daily
Duration

4-8 weeks

Intranasal administration. Some evidence suggests Semax may improve attention span and reduce hyperactivity symptoms.

Anxiety and Depression

200-500 mcg1× daily
Duration

4-8 weeks

Intranasal or subcutaneous. Preliminary research suggests potential mood-enhancing effects via modulation of dopamine and serotonin pathways.

Timing & Frequency

For cognitive enhancement, Semax is typically administered in the morning. Subcutaneous injections can be administered any time of day. Due to its short half-life, twice-daily dosing may be preferred for sustained effects. Avoid taking Semax close to bedtime to minimize potential sleep disturbances.

Cycle Guidance

Typical cycles range from 4–8 weeks, followed by a break of at least 4 weeks. While Semax does not significantly suppress endogenous systems, cycling is a common practice to prevent tolerance and minimize potential long-term side effects. Further research is needed to determine optimal cycling strategies.

Reconstitution Reference

Quick reference for reconstituting Semax. For custom vial sizes and concentrations, use the Reconstitution Calculator.

Common Vial SizeTypically 1 mg, 3 mg, or 5 mg per vial
BAC Water Volume1 mL bacteriostatic water for convenient intranasal administration
Concentration & DrawAt 1 mg/mL: 100 mcg = 0.1 mL (10 units on a 100-unit insulin syringe)
StorageRefrigerate at 2–8°C after reconstitution. Keep lyophilized powder at room temperature or refrigerated.
StabilityReconstituted solution stable up to 30 days refrigerated. Lyophilized powder stable 12–24 months per manufacturer specifications.
Use the Reconstitution Calculator → for precise injection volumes based on your exact vial size, water volume, and desired dose.

Frequently Asked Questions

What is the best way to administer Semax?
Intranasal administration is the most convenient and common method, allowing direct access to the brain. Subcutaneous injection is an alternative, but may be less efficient for cognitive enhancement.
Can I use Semax long-term?
Long-term safety data is limited. Most users cycle Semax to minimize potential tolerance and side effects. Consult with a healthcare professional before using Semax long-term.
What are the potential side effects of Semax?
Common side effects include anxiety, insomnia, and headaches. Less common side effects may include nasal irritation, increased blood pressure, and changes in appetite. Discontinue use if you experience any significant or concerning side effects.
Is Semax legal?
Semax is approved for medical use in Russia and Ukraine. It is not FDA-approved in the United States and its legal status varies by country. Consult with a legal professional to determine the legality of Semax in your jurisdiction.

Last updated: 2026-02-19