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Dosage GuideResearch Reference

NAD+ Dosage

Research-based dosing protocols, timing guidance, and reconstitution reference for NAD+. All information is for educational purposes only.

Quick Answer

NAD+ is typically administered via intravenous (IV) infusion or boosted through oral precursors like NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside). IV NAD+ dosages range from 250mg to 1000mg per infusion. Oral NMN/NR dosages range from 125mg to 1000mg daily. No formal dose-ranging trials exist; these recommendations are based on clinical usage and preliminary studies.

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Table of Contents

Standard Dosage Range

Research dosing range: 250–1000 mg (IV NAD+); 125–1000 mg (oral NMN/NR)

Educational reference only

These dosage ranges are derived from preclinical research and community protocols. No human clinical dose-ranging trials have established therapeutic doses for most research peptides. Always consult a qualified healthcare provider before starting any peptide protocol.

Dosage by Use Case

General Longevity / Anti-Aging

250–500 mg1–3× per week (IV NAD+); Daily (oral NMN/NR)
Duration

Ongoing (IV NAD+); 4–12+ weeks (oral NMN/NR)

Lower doses may be sufficient for maintenance. Some protocols use intermittent IV NAD+ infusions combined with daily oral NMN/NR supplementation.

Mitochondrial Dysfunction

500–1000 mg1–2× per week (IV NAD+); Daily (oral NMN/NR)
Duration

4–12 weeks

Higher doses may be needed to overcome severe mitochondrial impairment. Consider combining with other mitochondrial support nutrients (CoQ10, PQQ).

Neurodegenerative Conditions (Alzheimer's, Parkinson's)

500–1000 mg2–3× per week (IV NAD+); 500-1000mg Daily (oral NMN/NR)
Duration

Ongoing

Research is preliminary. Some clinicians use NAD+ as part of a broader neuroprotective protocol. Monitor for improvements in cognitive function and motor skills.

Metabolic Disorders (Insulin Resistance, Obesity)

250–500 mg1–2× per week (IV NAD+); 250-500mg Daily (oral NMN/NR)
Duration

8–12 weeks

Combine with lifestyle interventions (diet, exercise) for optimal results. Monitor for improvements in blood glucose and insulin sensitivity.

Addiction Recovery

500-1000 mgDaily for 5-10 days, then 2-3x/week (IV NAD+)
Duration

Variable, depending on individual needs

NAD+ infusions are sometimes used to support detoxification and reduce withdrawal symptoms. Protocol varies based on addiction severity and concurrent therapies.

Timing & Frequency

IV NAD+ infusions are typically administered over 2–4 hours. Oral NMN/NR is best taken in the morning or early afternoon. Avoid taking NMN/NR late in the day, as it may interfere with sleep in some individuals.

Cycle Guidance

There is no established cycling protocol for NAD+ precursors. Some practitioners recommend taking breaks from NMN/NR supplementation every few months to assess individual response and minimize potential adaptation. IV NAD+ infusions are often administered in a series of sessions followed by maintenance infusions as needed.

Reconstitution Reference

Quick reference for reconstituting NAD+. For custom vial sizes and concentrations, use the Reconstitution Calculator.

Common Vial SizeN/A (NAD+ IV infusions are pre-mixed by compounding pharmacies; NMN/NR come in pre-made capsules/powders)
BAC Water VolumeN/A
Concentration & DrawN/A
StorageNAD+ IV solutions should be stored according to the compounding pharmacy's instructions. NMN/NR supplements should be stored in a cool, dry place away from direct sunlight.
StabilityNAD+ IV solution stability varies by compounding pharmacy. NMN/NR supplement stability depends on the manufacturer's specifications.
Use the Reconstitution Calculator → for precise injection volumes based on your exact vial size, water volume, and desired dose.

Frequently Asked Questions

What is the optimal NAD+ dosage for longevity?
There is no consensus on the optimal NAD+ dosage for longevity. Dosages range from 250-500mg NAD+ via IV, 1-3 times a week, and 250-1000mg of NMN/NR daily. Individual responses vary. Starting with a lower dose and gradually increasing it may be prudent.
Are there any side effects associated with NAD+ supplementation?
IV NAD+ infusions can sometimes cause nausea, fatigue, stomach discomfort, or headaches. Oral NMN/NR is generally well-tolerated, but some individuals may experience flushing, itching, or gastrointestinal upset. Rare but serious side effects of IV NAD+ can include allergic reactions and arrhythmias. Always consult a healthcare professional before starting NAD+ supplementation.
How long does it take to see results from NAD+ supplementation?
The time it takes to see results from NAD+ supplementation varies depending on the individual and the specific condition being addressed. Some people may experience improvements in energy levels and cognitive function within a few weeks, while others may require several months to notice significant changes. Consistency is key.

Last updated: 2026-02-19