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Dosage GuideResearch Reference

Leuprolide Dosage

Research-based dosing protocols, timing guidance, and reconstitution reference for Leuprolide. All information is for educational purposes only.

Quick Answer

Leuprolide dosage varies widely based on the indication and formulation (daily subcutaneous injection vs. depot injection lasting 1-6 months). For prostate cancer, depot injections of 7.5mg to 45mg are typically administered monthly. For endometriosis and uterine fibroids, 3.75mg is commonly given monthly. Dosing for precocious puberty depends on the child's weight. Always follow a healthcare provider's specific instructions.

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Table of Contents

Standard Dosage Range

Research dosing range: 3.75-45 mg per month (depot injection), individualized based on indication and formulation.

Educational reference only

These dosage ranges are derived from preclinical research and community protocols. No human clinical dose-ranging trials have established therapeutic doses for most research peptides. Always consult a qualified healthcare provider before starting any peptide protocol.

Dosage by Use Case

Advanced Prostate Cancer

7.5-45 mgEvery 1 to 6 months (depot injection)
Duration

Continuous, long-term

Dosage and frequency depend on the specific depot formulation and the individual patient's response. Monitor PSA levels and testosterone.

Endometriosis

3.75 mgMonthly (depot injection)
Duration

6 months

Typically administered for a 6-month course. Add-back therapy (e.g., norethindrone acetate) may be considered to mitigate hypoestrogenic side effects.

Uterine Fibroids

3.75 mgMonthly (depot injection)
Duration

3-6 months

Administered prior to surgery to reduce fibroid size and bleeding. Add-back therapy may be considered.

Central Precocious Puberty

7.5-15 mgEvery 1 to 3 months (depot injection)
Duration

Until appropriate pubertal age

Dosage based on weight. Monitor LH, FSH, and estradiol levels. Regular monitoring of bone age is crucial.

Controlled Ovarian Stimulation (IVF)

Variable; typically 1 mg/day (subcutaneous injection) or single depot injectionDaily or single injection
Duration

Until hCG administration

Used to prevent premature LH surge. Dosage and timing are highly individualized in IVF protocols. Requires close monitoring by a fertility specialist.

Timing & Frequency

Leuprolide depot injections are administered according to the prescribed schedule (e.g., every month, every 3 months). Subcutaneous injections are typically administered daily at the same time each day.

Cycle Guidance

For prostate cancer, leuprolide is often used continuously long-term. For endometriosis and uterine fibroids, treatment is typically limited to 6 months to minimize bone loss. Monitoring bone density is recommended with prolonged use. For precocious puberty, treatment continues until an appropriate age for puberty is reached.

Reconstitution Reference

Quick reference for reconstituting Leuprolide. For custom vial sizes and concentrations, use the Reconstitution Calculator.

Common Vial SizeVaries based on formulation and manufacturer.
BAC Water VolumeFollow manufacturer's instructions for the specific formulation.
Concentration & DrawVaries based on formulation and manufacturer. Consult product label for concentration after reconstitution.
StorageRefrigerate after reconstitution if required by the manufacturer. Follow product-specific instructions.
StabilityRefer to the manufacturer's instructions for the specific formulation regarding stability after reconstitution.
Use the Reconstitution Calculator → for precise injection volumes based on your exact vial size, water volume, and desired dose.

Frequently Asked Questions

What is the typical leuprolide dosage for prostate cancer?
The typical leuprolide dosage for prostate cancer depends on the depot formulation and ranges from 7.5 mg to 45 mg administered every 1 to 6 months. Individualized dosing is determined by the physician based on disease severity and patient response.
How long can leuprolide be used for endometriosis?
Leuprolide is typically used for a maximum of 6 months for endometriosis to minimize the risk of bone loss. Add-back therapy may be considered.
What happens if I miss a leuprolide injection?
Contact your healthcare provider immediately if you miss a leuprolide injection. Do not double the dose to catch up.
Are there any long-term side effects of leuprolide treatment?
Long-term leuprolide treatment can lead to bone loss, hot flashes, decreased libido, and other side effects associated with low sex hormone levels. Regular monitoring and management of side effects are important.

Last updated: 2026-02-19