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Dosage GuideResearch Reference

Goserelin Dosage

Research-based dosing protocols, timing guidance, and reconstitution reference for Goserelin. All information is for educational purposes only.

Quick Answer

Goserelin (Zoladex) is administered as a subcutaneous implant, typically in the anterior abdominal wall. The standard dosages are 3.6 mg every 28 days or 10.8 mg every 3 months, depending on the indication. Dosage is consistent across approved indications.

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Table of Contents

Standard Dosage Range

Research dosing range: 3.6 mg every 28 days or 10.8 mg every 3 months

Educational reference only

These dosage ranges are derived from preclinical research and community protocols. No human clinical dose-ranging trials have established therapeutic doses for most research peptides. Always consult a qualified healthcare provider before starting any peptide protocol.

Dosage by Use Case

Prostate Cancer

3.6 mgEvery 28 days
Duration

Continuous, as directed by physician

Administered subcutaneously. Used for palliative treatment of advanced prostate cancer. Monitor PSA and testosterone levels.

Breast Cancer (Premenopausal)

3.6 mgEvery 28 days
Duration

Continuous, as directed by physician

Administered subcutaneously. Used for hormone receptor-positive breast cancer. Monitor estradiol levels.

Endometriosis

3.6 mgEvery 28 days
Duration

6 months

Administered subcutaneously. Used for pain relief and reduction of endometrial lesions. Not recommended for longer than 6 months due to bone density loss concerns.

Endometrial Thinning (Pre-Ablation)

3.6 mgEvery 28 days
Duration

1-2 months prior to surgery

Administered subcutaneously. Used to thin the endometrial lining to improve ablation outcomes.

Timing & Frequency

Goserelin is administered via subcutaneous injection. The implant slowly releases the drug over the specified period (28 days or 3 months). There are no specific timing considerations beyond adherence to the scheduled injection date.

Cycle Guidance

Goserelin treatment duration depends on the specific indication. For prostate cancer and breast cancer, treatment can be continuous. For endometriosis, it is typically limited to 6 months. Regular monitoring of hormone levels and bone density is recommended during long-term use.

Reconstitution Reference

Quick reference for reconstituting Goserelin. For custom vial sizes and concentrations, use the Reconstitution Calculator.

Common Vial SizePre-filled syringe containing the implant
BAC Water VolumeN/A - Pre-filled implant
Concentration & Draw3.6 mg or 10.8 mg per implant
StorageStore at room temperature, protected from light.
StabilityStable until expiration date on the package.
Use the Reconstitution Calculator → for precise injection volumes based on your exact vial size, water volume, and desired dose.

Frequently Asked Questions

What is the dosage of goserelin for prostate cancer?
The standard dosage for prostate cancer is 3.6 mg injected subcutaneously every 28 days or 10.8 mg injected subcutaneously every 3 months, as directed by a physician.
How often should goserelin be administered for endometriosis?
For endometriosis, goserelin is typically administered as a 3.6 mg subcutaneous implant every 28 days for a duration of 6 months. It is not recommended for longer use due to potential bone density loss.
What are the potential side effects of goserelin?
Common side effects include hot flashes, decreased libido, erectile dysfunction, vaginal dryness, bone density loss, and mood changes. Consult with your doctor for a complete list and management strategies.

Last updated: 2026-02-19