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Dosage GuideResearch Reference

GHK Dosage

Research-based dosing protocols, timing guidance, and reconstitution reference for GHK. All information is for educational purposes only.

Quick Answer

Limited human data exists for GHK dosing. Topical formulations are widely used in cosmeceutical skincare. Some researchers explore subcutaneous injections, while others focus on oral supplementation, although bioavailability of oral GHK is not fully established. Dosage considerations must account for GHK’s rapid copper-binding activity in vivo, forming GHK-Cu.

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Table of Contents

Standard Dosage Range

Research dosing range: Topical: Manufacturer’s recommendations. Subcutaneous: 50–200 mcg daily (experimental). Oral: 250-1000mcg daily (experimental).

Educational reference only

These dosage ranges are derived from preclinical research and community protocols. No human clinical dose-ranging trials have established therapeutic doses for most research peptides. Always consult a qualified healthcare provider before starting any peptide protocol.

Dosage by Use Case

Topical Skin Rejuvenation

Follow product instructions1–2× daily
Duration

Ongoing

Apply to clean skin. Common in serums, creams, and lotions. May be combined with other anti-aging ingredients.

Wound Healing (experimental)

50–100 mcg1× daily
Duration

2–4 weeks

Subcutaneous injection near wound site. Limited human data. Use with caution and monitor for adverse reactions.

Anti-Inflammatory (experimental)

100-200 mcg1× daily
Duration

4–8 weeks

Subcutaneous injection. Based on preclinical data. Monitor inflammatory markers if possible.

Oral Supplementation (experimental)

250-1000 mcg1-2x daily
Duration

4-12 weeks

Oral capsules or powder. Bioavailability is uncertain. Monitor for gastrointestinal side effects.

Timing & Frequency

Topical applications are usually recommended morning and evening. Subcutaneous injections are often administered in the morning. Oral dosing can be taken with or without food.

Cycle Guidance

Due to limited human data, cycling is a conservative approach. A common experimental protocol involves a 6–8 week cycle followed by a 4-week break. Monitor for any adverse effects and adjust accordingly.

Reconstitution Reference

Quick reference for reconstituting GHK. For custom vial sizes and concentrations, use the Reconstitution Calculator.

Common Vial SizeTypically 1 mg or 5 mg per vial (research grade)
BAC Water Volume1 mL bacteriostatic water for 1 mg/mL or 5mg/mL concentration, respectively.
Concentration & DrawAt 1 mg/mL: 50 mcg = 0.05 mL (5 units on a 100-unit insulin syringe). At 5 mg/mL: 50 mcg = 0.01 mL (1 unit on a 100-unit insulin syringe).
StorageRefrigerate at 2–8°C after reconstitution. Keep lyophilized powder at room temperature or refrigerated.
StabilityReconstituted solution stable up to 7 days refrigerated. Lyophilized powder stable 12-24 months per manufacturer specifications.
Use the Reconstitution Calculator → for precise injection volumes based on your exact vial size, water volume, and desired dose.

Frequently Asked Questions

What is the typical topical dosage of GHK?
Follow the manufacturer’s recommendations for the specific product. Concentrations and application instructions vary widely.
Is oral GHK effective?
Oral bioavailability is not well established. Some individuals report benefits, but more research is needed to confirm efficacy and optimal dosing.
How should I store reconstituted GHK?
Refrigerate at 2–8°C. Use within 7 days for best results. Lyophilized powder should be stored as per the manufacturer’s recommendations.

Last updated: 2026-02-19