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Dosage GuideResearch Reference

Davunetide Dosage

Research-based dosing protocols, timing guidance, and reconstitution reference for Davunetide. All information is for educational purposes only.

Quick Answer

In clinical trials, davunetide (NAP) has been administered intranasally at doses ranging from 6 mg to 30 mg daily. The optimal dosage and frequency for various conditions are still under investigation.

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Table of Contents

Standard Dosage Range

Research dosing range: 6–30 mg daily (intranasal)

Educational reference only

These dosage ranges are derived from preclinical research and community protocols. No human clinical dose-ranging trials have established therapeutic doses for most research peptides. Always consult a qualified healthcare provider before starting any peptide protocol.

Dosage by Use Case

Amnestic Mild Cognitive Impairment (aMCI)

30 mg1× daily
Duration

12 months

Dose used in Phase II clinical trials showing cognitive benefits. Administered via intranasal spray.

Progressive Supranuclear Palsy (PSP)

30 mg2× daily
Duration

52 weeks

Dose used in failed Phase II/III trial. While ineffective for PSP overall, subgroup analysis suggested potential benefits in certain patients.

ADNP Syndrome

Individualized; typically starting at 6mg/day1-2x daily
Duration

Ongoing

Dosing varies based on patient age, weight, and symptom severity. Administered intranasally. Requires close monitoring by a physician specialized in ADNP syndrome.

Cognitive Enhancement (Experimental)

6-15mg1x daily
Duration

4-8 weeks

Intranasal administration. Limited human data exists outside of clinical trials. Consider starting at lower end of range.

Timing & Frequency

Davunetide is typically administered intranasally in the morning or evening. The timing may be adjusted based on individual preferences and tolerance.

Cycle Guidance

Clinical trials have used davunetide for up to 12 months. Cycling is not strictly necessary but may be considered to assess ongoing efficacy and minimize potential long-term effects. Consult with a healthcare professional for personalized guidance.

Reconstitution Reference

Quick reference for reconstituting Davunetide. For custom vial sizes and concentrations, use the Reconstitution Calculator.

Common Vial SizeTypically supplied as a pre-filled nasal spray
BAC Water VolumeN/A (pre-filled spray)
Concentration & DrawConcentration varies depending on the formulation (typically provides a specific mg dose per spray)
StorageStore at recommended temperature per manufacturer instructions, typically refrigerated or at room temperature.
StabilityFollow manufacturer expiry date on the packaging.
Use the Reconstitution Calculator → for precise injection volumes based on your exact vial size, water volume, and desired dose.

Frequently Asked Questions

What is the standard davunetide dosage for cognitive impairment?
Clinical trials for amnestic mild cognitive impairment (aMCI) used a dosage of 30 mg daily administered intranasally.
How is davunetide administered?
Davunetide is administered via intranasal spray.
What are the potential side effects of davunetide?
Common side effects reported in clinical trials include nasal congestion, headache, and mild irritation. More serious side effects are rare.

Last updated: 2026-02-19