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Dosage GuideResearch Reference

Cetrorelix Dosage

Research-based dosing protocols, timing guidance, and reconstitution reference for Cetrorelix. All information is for educational purposes only.

Quick Answer

Cetrorelix is typically administered at 0.25 mg daily via subcutaneous injection, or as a single 3 mg depot injection. The daily dose is used in IVF protocols, while the depot injection is used when sustained LH suppression is needed. No human clinical dose-ranging trials have been completed outside of reproductive medicine indications.

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Table of Contents

Standard Dosage Range

Research dosing range: 0.25 mg daily (SC) or 3 mg single depot injection (SC)

Educational reference only

These dosage ranges are derived from preclinical research and community protocols. No human clinical dose-ranging trials have established therapeutic doses for most research peptides. Always consult a qualified healthcare provider before starting any peptide protocol.

Dosage by Use Case

Prevention of Premature LH Surge (IVF)

0.25 mg1× daily
Duration

Varies based on ovarian stimulation protocol

Subcutaneous injection. Administered during the late follicular phase of controlled ovarian stimulation, typically starting on cycle day 5-7 and continuing until hCG administration.

Sustained LH Suppression (IVF)

3 mgSingle injection
Duration

Up to 4 days

Subcutaneous depot injection. Used to provide sustained LH suppression, often initiated on cycle day 7-8. May be followed by daily 0.25 mg injections if longer suppression is required.

Endometriosis Symptom Management (Off-label)

0.25 mg1× daily
Duration

Up to 6 months (limited data)

Subcutaneous injection. Research is preliminary. Continuous use beyond 6 months is not recommended due to potential bone density loss.

Uterine Fibroid Symptom Management (Off-label)

0.25 mg1× daily
Duration

Up to 6 months (limited data)

Subcutaneous injection. Research is preliminary. Intermittent use (e.g., 3 months on, 3 months off) may mitigate bone density effects.

Benign Prostatic Hyperplasia (BPH) (Off-label)

0.25 mg1× daily
Duration

Variable (limited data)

Subcutaneous injection. Used as an alternative to GnRH agonists, aiming to avoid the initial testosterone surge. Clinical trials are limited.

Timing & Frequency

For IVF, the 0.25 mg daily injection is typically administered in the morning or evening, as directed by the IVF protocol. The 3 mg depot injection is a single administration. For off-label uses, the injection timing is not critical but should be consistent each day.

Cycle Guidance

For IVF, cetrorelix is used as part of a larger controlled ovarian stimulation protocol. For off-label uses, cycles are typically limited to 6 months due to potential bone density loss. Intermittent cycling may be considered.

Reconstitution Reference

Quick reference for reconstituting Cetrorelix. For custom vial sizes and concentrations, use the Reconstitution Calculator.

Common Vial SizeTypically 0.25 mg or 3 mg per vial (depending on formulation)
BAC Water Volume1 mL sterile water for injection (for 0.25mg vial)
Concentration & Draw0.25 mg/mL (for 0.25mg vial). The 3 mg depot formulation is typically pre-mixed.
StorageRefrigerate at 2–8°C after reconstitution. Keep lyophilized powder at room temperature or refrigerated.
StabilityReconstituted solution should be used immediately. Lyophilized powder stable per manufacturer specifications.
Use the Reconstitution Calculator → for precise injection volumes based on your exact vial size, water volume, and desired dose.

Frequently Asked Questions

What is the standard cetrorelix dosage for IVF?
The standard dosage is 0.25 mg daily via subcutaneous injection, starting during the late follicular phase of controlled ovarian stimulation. Alternatively, a single 3 mg depot injection can be used for sustained LH suppression.
Can cetrorelix be taken orally?
No, cetrorelix is not bioavailable orally. It must be administered via subcutaneous injection.
What is the half-life of cetrorelix?
The half-life is dose-dependent, approximately 5 hours for the 0.25 mg dose and 20-60 hours for the 3 mg depot dose.
What are the potential side effects of cetrorelix?
Common side effects include injection site reactions, headache, and nausea. Long-term use may be associated with bone density loss.
Is cetrorelix a GnRH agonist or antagonist?
Cetrorelix is a GnRH antagonist. It blocks the GnRH receptor without causing an initial hormonal flare.

Last updated: 2026-02-19