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Dosage GuideResearch Reference

Anamorelin Dosage

Research-based dosing protocols, timing guidance, and reconstitution reference for Anamorelin. All information is for educational purposes only.

Quick Answer

The approved dosage of anamorelin (Adlumiz) is 100 mg taken orally once daily on an empty stomach, at least 1 hour before the first meal of the day. It is approved in Japan for cancer cachexia in patients with specific advanced cancers. No dose-ranging studies exist for other conditions.

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Table of Contents

Standard Dosage Range

Research dosing range: 100 mg once daily (oral)

Educational reference only

These dosage ranges are derived from preclinical research and community protocols. No human clinical dose-ranging trials have established therapeutic doses for most research peptides. Always consult a qualified healthcare provider before starting any peptide protocol.

Dosage by Use Case

Cancer Cachexia (Non-Small Cell Lung Cancer)

100 mg1× daily
Duration

12 weeks (ROMANA trial duration)

Approved for inoperable advanced or recurrent non-small cell lung cancer. Take on an empty stomach.

Cancer Cachexia (Gastric Cancer)

100 mg1× daily
Duration

Ongoing (per physician discretion)

Approved in Japan for gastric cancer-related cachexia. Monitor blood glucose levels regularly.

Cancer Cachexia (Pancreatic Cancer)

100 mg1× daily
Duration

Ongoing (per physician discretion)

Approved in Japan for pancreatic cancer-related cachexia. Consider QTc interval monitoring in high-risk patients.

Cancer Cachexia (Colorectal Cancer)

100 mg1× daily
Duration

Ongoing (per physician discretion)

Approved in Japan for colorectal cancer-related cachexia. Be aware of potential drug interactions.

Timing & Frequency

Anamorelin should be taken on an empty stomach at least one hour before the first meal of the day to maximize absorption. Consistency in timing is recommended.

Cycle Guidance

In the ROMANA trials, anamorelin was administered for 12 weeks. The optimal duration of therapy has not been definitively established, and long-term use should be guided by a physician.

Reconstitution Reference

Quick reference for reconstituting Anamorelin. For custom vial sizes and concentrations, use the Reconstitution Calculator.

Common Vial SizeN/A (oral tablet)
BAC Water VolumeN/A (oral tablet)
Concentration & DrawN/A (oral tablet)
StorageStore tablets as directed by the manufacturer, typically at room temperature, away from moisture and light.
StabilityRefer to the manufacturer's expiration date on the packaging.
Use the Reconstitution Calculator → for precise injection volumes based on your exact vial size, water volume, and desired dose.

Frequently Asked Questions

What is the approved dosage of anamorelin?
The approved dosage is 100 mg taken orally once daily on an empty stomach, at least 1 hour before the first meal. This is based on the ROMANA phase 3 clinical trials.
Does food affect anamorelin absorption?
Yes, food significantly reduces anamorelin absorption. Taking it on an empty stomach maximizes its bioavailability and effectiveness.
How long should I take anamorelin?
The ROMANA trials lasted 12 weeks, and the duration of treatment should be guided by a physician based on individual patient needs and response to therapy.
Can anamorelin be used for muscle wasting from other conditions besides cancer?
Anamorelin is currently only approved for cancer-related cachexia in Japan. Its use for other wasting conditions is off-label and lacks sufficient clinical evidence.
What if I miss a dose of anamorelin?
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

References

  1. 1
    Anamorelin for patients with cancer cachexia: ROMANA 1 and ROMANA 2 phase 3 trials(2015)PubMed ↗
  2. 2
    Anamorelin for the treatment of cancer anorexia-cachexia: ROMANA 3 extension trial(2017)PubMed ↗
  3. 3
    Pharmacokinetics and pharmacodynamics of anamorelin hydrochloride in healthy Japanese male subjects.(2014)PubMed ↗

Last updated: 2026-02-19