Oral administration
Delivery of a peptide by mouth in tablet or capsule form. Most peptides have poor oral bioavailability due to enzymatic degradation in the GI tract, though new formulations like oral semaglutide (Rybelsus) use absorption enhancers.
Frequently Asked Questions
What is Oral administration?
Why is Oral administration important in peptide research?
Related Terms
The fraction of an administered dose that reaches systemic circulation unchanged. Subcutaneous injection provides 65–95% bioavailability for most peptides; oral bioavailability is typically below 1% without absorption enhancers.
First-pass metabolismThe metabolism of an orally administered peptide by the gut wall and liver before it reaches systemic circulation. First-pass effect dramatically reduces oral bioavailability for most peptides.
Sublingual administrationPlacement of a peptide under the tongue for absorption through the oral mucosa. Bypasses first-pass metabolism and provides faster onset than oral administration, though bioavailability varies by peptide.
Related Peptide Profiles
A GLP-1 receptor agonist FDA-approved for type 2 diabetes (Ozempic) and weight management (Wegovy). Reduces appetite and slows gastric emptying.
OrforglipronAn investigational oral non-peptide GLP-1 receptor agonist. If approved, would be the first oral GLP-1 that doesn’t require fasting before dosing.