Hepatic metabolism
The breakdown of peptides by liver enzymes. Most peptides are degraded by proteases rather than CYP450 enzymes, which means fewer drug-drug interactions compared to small-molecule drugs.
Frequently Asked Questions
What is Hepatic metabolism?
Why is Hepatic metabolism important in peptide research?
Related Terms
The metabolism of an orally administered peptide by the gut wall and liver before it reaches systemic circulation. First-pass effect dramatically reduces oral bioavailability for most peptides.
CYP450Cytochrome P450, a superfamily of liver enzymes responsible for metabolizing most small-molecule drugs. Peptides are primarily degraded by proteases, not CYP450, which reduces their drug interaction potential.
Renal clearanceThe removal of a peptide from the blood by the kidneys. Smaller peptides (below ~60 kDa) are filtered by the glomerulus. PEGylation increases molecular size to reduce renal clearance and extend half-life.
Clearance rateThe volume of blood from which a peptide is completely removed per unit time, expressed in mL/min or L/hr. Clearance determines dosing frequency along with half-life.