Skip to content
Pharmacology & Mechanisms

Blood-brain barrier

A semi-permeable membrane of endothelial cells that separates circulating blood from brain tissue. Most peptides cannot cross the BBB, which is why intranasal delivery is used for neuroactive peptides like Selank and Semax.

Frequently Asked Questions

What is Blood-brain barrier?
A semi-permeable membrane of endothelial cells that separates circulating blood from brain tissue. Most peptides cannot cross the BBB, which is why intranasal delivery is used for neuroactive peptides like Selank and Semax.
Why is Blood-brain barrier important in peptide research?
Blood-brain barrier is a key pharmacological concept that determines how peptides interact with the body. Understanding this term helps practitioners optimize dosing protocols, predict therapeutic outcomes, and minimize side effects.

Related Terms

Intranasal administration

Delivery of a peptide through the nasal mucosa, bypassing the blood-brain barrier for some compounds. Used for peptides like Selank and Semax that target the central nervous system.

Bioavailability

The fraction of an administered dose that reaches systemic circulation unchanged. Subcutaneous injection provides 65–95% bioavailability for most peptides; oral bioavailability is typically below 1% without absorption enhancers.

Related Peptide Profiles

Selank

A synthetic heptapeptide analog of tuftsin with anxiolytic and nootropic properties. Modulates serotonin, dopamine, and BDNF without sedation.

Semax

A synthetic heptapeptide derived from ACTH(4-10) with neuroprotective and cognitive-enhancing properties. Approved in Russia for stroke and cognitive disorders.

Dihexa

A synthetic hexapeptide analog of angiotensin IV studied for cognitive enhancement. Shown to be 10 million times more potent than BDNF in some assays.

← Back to full glossary